Results 91 to 100 of about 41,015 (284)

ProgModule: A novel computational framework to identify mutation driver modules for predicting cancer prognosis and immunotherapy response

Journal of Translational Medicine
Background Cancer originates from dysregulated cell proliferation driven by driver gene mutations. Despite numerous algorithms developed to identify genomic mutational signatures, they often suffer from high computational complexity and limited clinical ...
Xiangmei Li, Bingyue Pan, Xilong Zhao, Yinchun Su, Jiyin Lai, Siyuan Li, Yalan He, Jiashuo Wu, Junwei Han   +8 more
doaj   +1 more source

Distributed Application Extensions and Obsolescence as Risk Generating Factors [PDF]

Informatică economică, 2012
Extending distributed IT&C applications raises risks associated to integrating new modules in already existing functional areas, influencing performance and data relevancy.
Catalin Alexandru TĂNASIE
doaj  

Representation of Balancing Options for Variable Renewables in Long-Term Energy System Models: An Application to OSeMOSYS

Energies, 2019
The growing complexity and the many challenges related to fast-changing and highly de-carbonised electricity systems require reliable and robust open source energy modelling frameworks. Their reliability may be tested on a series of well-posed benchmarks
Francesco Gardumi, Manuel Welsch, Mark Howells, Emanuela Colombo   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

RATIONALLY INJECTIVE MODULES [PDF]

, 2015
In this work we introduce the concept of rationally injective module, which is a proper generalization of (essentially)-injective modules. Several properties and characterizations have been given. In part of this work, we find sufficient conditions for a
Abbas, Mehdi Sadiq, Nayef, Mahdi Saleh
core   +1 more source

Functional predictability of universal gene circuits in diverse microbial hosts

Quantitative Biology
Although the principles of synthetic biology were initially established in model bacteria, microbial producers, extremophiles and gut microbes have now emerged as valuable prokaryotic chassis for biological engineering.
Chenrui Qin, Tong Xu, Xuejin Zhao, Yeqing Zong, Haoqian M. Zhang, Chunbo Lou, Qi Ouyang, Long Qian   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Generalized extending modules via exchange and clean properties

, 2019
A module is called extending or CS provided that every submodule is essential in a direct summand. There have been investigations of several generalized extending conditions in the literature.
TERCAN, ADNAN, KARA ŞEN, YELİZ
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Extending Property and Related Concepts

, 2016
Not ...
TERCAN, ADNAN, Tercan, A, Yücel, Canan Celep, Adnan Tercan, Canan C. Yücel, CELEP YÜCEL, CANAN   +5 more
core   +1 more source