Results 121 to 130 of about 915,178 (269)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Jixie chuandong, 2012 A CAD system of CHC type reducer with few teeth difference is developed in Visual Basic 6.0 integrated programming environment.Two modules,calculating for design and parametric drawing are included in the system,which are communicated effectively by ...
陈满意, 黄忠敏, 石永科
doaj
Precise three-diode photovoltaic model for photovoltaic modules based on Puma optimizer
Ain Shams Engineering JournalThe modeling accuracy of photovoltaic (PV) modules is essential nowadays due to the spread of PV power plant installation. Thus, precise PV modeling is vital as it ensures the optimal design, reliable performance prediction, and efficient energy ...
Dina A. Zaki +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Journal of Facade Design and EngineeringTo assist the sustainable development of the building sector, designers require tools illustrating the most viable design options. This paper, starting by presenting the opportunities and limitations of the Life Cycle Assessment (LCA) methodology and ...
Luca Morganti +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Endotrivial modules for the symmetric and alternating groups. [PDF]
, 2009 In this paper we determine the group of endotrivial modules for certain symmetric and alternating groups in characteristic $p$. If $p=2$, then the group is generated by the class of $\Omega^n(k)$ except in a few low degrees.
Mazza, Nadia +2 more
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source