Results 121 to 130 of about 259,780 (278)

MC21 v.10 – coupled-radiation Monte Carlo transport solver with support for multiphysics simulations

EPJ Nuclear Sciences & Technologies
Over the past decade, the development of the MC21 Monte Carlo radiation transport solver has focused on extending the functionality of the code beyond static calculations of reactivity and reaction rate distributions, as well as improving accuracy ...
Griesheimer David P., Gill Daniel F., Nease Brian R., Pavlou Andrew, Stedry Mark H., Thompson Jason T., Burke Paul E., Dobreff Peter S.   +7 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

On generalized FI-extending modules

, 2020
Summary: A module \(M\) is called \textit{FI-extending} if every fully invariant submodule of \(M\) is essential in a direct summand of \(M\). In this work, we define a module \(M\) to be \textit{generalized FI-extending (GFI-extending)} if for any fully invariant submodule \(N\) of \(M\), there exists a direct summand \(D\) of \(M\) such that \(N \leq
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mono- and multidomain defense toxins of the RelE/ParE superfamily

mBio
Toxin–antitoxin (TA) modules are widely distributed across prokaryotes, often existing in large numbers despite their associated fitness costs. Most type II TA modules are bicistronic operons encoding a monodomain toxin and its cognate protein antitoxin.
Kenn Gerdes
doaj   +1 more source

On K-extending modules

Tamkang Journal of Mathematics, 2017
Let $M$ be a right $R$-module and $S=End_R(M)$. We call $M$ a $\mathcal{K}$-extending module if for every element $\phi\in S$, Ker$\phi$ is essential in a direct summand of $M$. In this paper we investigate these modules. We give a characterization of $\mathcal{K}$-extending modules.
openaire   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Jacobi–Jordan Conformal Algebras: Basics, Constructions and Related Structures

Mathematics
The main purpose of this paper is to introduce and investigate the notion of Jacobi–Jordan conformal algebras. They are a generalization of Jacobi–Jordan algebras which correspond to the case in which the formal parameter λ equals 0.
Taoufik Chtioui, Sami Mabrouk, Abdenacer Makhlouf   +2 more
doaj   +1 more source