Results 161 to 170 of about 915,178 (269)

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex. [PDF]

Nature
Yang H, Clarence T, Scott MR, Wang X, N M P, Pjanic M, Venkatesh S, Hong A, Casey C, Murphy SR, Shao Z, Alvia M, Argyriou S, Yu AK, PsychAD Consortium, Tsankova NM, Auluck PK, Marenco S, Haroutunian V, Voloudakis G, Bendl J, McClung CA, Lee D, Fullard JF, Hoffman GE, Girdhar K, Roussos P.   +26 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Wafer-level meta-aspheric lenses for compact wide-FOV NIR imaging. [PDF]

Light Sci Appl
Lee E, Rho J.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

RNA m6A modification-regulated ferroptosis in cancer: mechanism and therapeutic potential. [PDF]

Front Cell Dev Biol
Shi Q, Li Y, Guan C.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cellular hallmarks and aging clock of the human lung parenchyma. [PDF]

Nat Commun
Xu K, Kim GS, Bhagwat A, Meimand SE, Venkat VV, Pham G, Zhang J, Abdul-Ghafar J, Bairakdar MD, Dolasia K, Sahasrabudhe IR, Klausner A, Chen Y, Nguyen TT, Giotti B, Brody R, Kim SJ, Kathiriya JJ, Puleston DJ, Lee PJ, Tsankov AM.   +20 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Smart cellular bricks for decentralized shape classification and damage recovery. [PDF]

Nat Commun
Moreno R, Faíña A, Sudhakaran S, Walker K, Risi S.   +4 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source