Results 111 to 120 of about 915,178 (269)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Single IGBT Open‐Circuit Fault Mitigation in Cascaded Converters Using Zero‐Mode Control and Half‐Wave Reconfiguration Composite Control

Energy Science & Engineering
This article proposes a composite fault‐tolerant control strategy combining zero‐mode control and half‐wave reconfiguration to address single IGBT open‐circuit faults in cascaded H‐bridge converters.
Lei Dong, Hanqiang Wang, Hao Jin, Rende Zhao, Member, IEEE, Huihui Hu   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Design and Improvement of an Automated Tool for Quality Control and Performance Assessment of Photovoltaic Modules

Solar
Photovoltaic (PV) systems are at the heart of the energy transition, providing an essential source of clean, renewable energy for applications such as solar pumping, which is essential for irrigation and rural water supply.
Alain Foutche Tchouli, Stephane Ndiya Ngasop, Jean Hilaire Tchami, Claude Bertin Nzoundja Fapi, Hyacinthe Tchakounté   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Representation of 3D Land Cover Data in Semantic City Models

ISPRS International Journal of Geo-Information
A large number of cities have created semantic 3D city models, but these models are rarely used as input data for simulations, such as noise and flooding, in the urban planning process.
Per-Ola Olsson, Axel Andersson, Matthew Calvert, Axel Loreman, Erik Lökholm, Emma Martinsson, Karolina Pantazatou, Björn Svensson, Alex Spielhaupter, Maria Uggla, Lars Harrie   +10 more
doaj   +1 more source

Structuring of specification modules (extended)

Comput. Sci. J. Moldova, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Extending irreducible modules

Journal of Algebra, 1981
An important part of Clifford’s theory does not work properly for arbitrary fields R. To see why, we must recall the main steps of this theory. We are interested in extensions to RH-modules of a fixed H-invariant irreducible RN-module a, where N is a normal subgroup of a finite group H. We first pass to the factor algebra ‘u = RH/3 modulo the ideal 3 =
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source