Results 101 to 110 of about 320,638 (309)
HD Maps for Autonomous Vehicles: Implications for Cartographic Theory and Practice
High-Definition (HD) Maps have become a cornerstone of autonomous vehicle (AV) technology, enabling precise localization, perception, and decision-making.
Dariusz Gotlib +2 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Finite-to-One Maps and Open Extensions of Maps [PDF]
In the class of p-spaces it is shown that (a) infinite weight is not lowered by finite-to-one maps which are open except at finitely many points, (b) metrizability is inversely preserved under finiteto-one maps which are open except at finitely many points.
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Visually Plotting Importance and Satisfaction to Identify Extension Clients’ Needs
This is the second document in the Importance-performance Analysis series, a series of three about using importance-performance analysis (IPA) to prioritize Extension resources.
Anil Kumar Chaudhary, Laura A. Warner
doaj +1 more source
Extension of bilipschitz maps of compact polyhedra.
Let \(K \subset \mathbb{R}^ n\) be a compact polyhedron and let \(Y\) be an at least \(n\)-dimensional linear subspace of the Hilbert space \(\ell_ 2\). A map \(f:K \to Y\) is said to be \(L\)-bilipschitz if \(L \geq 1\) and \[ {| x-y | \over L} \leq | fx-fy | \leq L | x-y | \] for all \(x,y \in K\). Although simple examples show that in general an \(L\
Väisälä, Jussi, Partanen, Juha
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The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
A set of necessary and sufficient conditions under which an isotone mapping from a subset of a poset X to a poset Y has an extension to an isotone mapping from X to Y are found.
openaire +2 more sources

