Results 121 to 130 of about 166,127,910 (213)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Virginia Cooperative Extension Volunteers: Extending Knowledge and Improving Lives

open access: yes, 2015
This publication reviews the volunteer screening process for the Virginia Cooperative ...

core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Lancement MAPS 7

open access: yes, 2014
La session MAPS 7 aura lieu en 2014 à Seignosse, dans les Landes, du dimanche 29 juin au soir au vendredi 4 juillet midi). L'objet de cette édition est de proposer aux membres "fidèles" de MAPS un atelier de réflexion sur les échelles de la modélisation.
Réseau MAPS
core  

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Virginia Seafood Agricultural Research and Extension Center Fact Sheet

open access: yes, 2017
Provides information about the Virginia Seafood Agricultural Research and Extension Center in Hampton ...
Schwarz, Michael H.
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Recueil des fiches pédagogiques MAPS en PDF

open access: yes, 2014
Vous pouvez télécharger le PDF contenant l'intégralité des fiches pédagogiques MAPS sur la page des productions MAPS Vous trouverez également ce recueil de fiches pédagogiques des éditions de MAPS de 2009 à 2013 sur le site HAL : https://hal.archives ...
Réseau MAPS
core  

Functional compression-expansion fixed point theorem

open access: yesElectronic Journal of Differential Equations, 2008
This paper presents a generalization of the fixed point theorems of compression and expansion of functional type. As an application, the existence of a positive solution to a second order conjugate boundary value problem is considered. We conclude
Donal O'regan   +2 more
doaj  

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