Results 121 to 130 of about 168 (168)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
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Canadian Journal of Mathematics, 1970
In recent years there has been some interest in trying to improve the behaviour of maps by extending their domains. For example, in 1953 Whyburn showed that every map is the restriction of a compact map [17]. Similarly, Krolevec proved in 1967 that each locally perfect map can be extended to a perfect map [12] and in an as yet unpublished paper ...
Franklin, S. P., Kohli, J. K.
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In recent years there has been some interest in trying to improve the behaviour of maps by extending their domains. For example, in 1953 Whyburn showed that every map is the restriction of a compact map [17]. Similarly, Krolevec proved in 1967 that each locally perfect map can be extended to a perfect map [12] and in an as yet unpublished paper ...
Franklin, S. P., Kohli, J. K.
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Mapping Extension of an Algebra
Algebra Colloquium, 2009A new construction of algebras called a mapping extension of an algebra is here introduced. The construction yields a generalization of some classical constructions such as the nilpotent extension of an algebra, inflation of a semigroup but also the square extension construction introduced recently for idempotent groupoids.
Marczak, Adam W., Płonka, Jerzy
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The Annals of Mathematics, 1960
In ? 2 we provide some criteria for the extension of 7. These are applied to prove stability theorems for families of complex structures (? 3 and ? 4), particularly complex structures uniformizable on bounded domains of the complex number space and of complex toral structures. In ?
Andreotti, Aldo, Stoll, Wilhelm
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In ? 2 we provide some criteria for the extension of 7. These are applied to prove stability theorems for families of complex structures (? 3 and ? 4), particularly complex structures uniformizable on bounded domains of the complex number space and of complex toral structures. In ?
Andreotti, Aldo, Stoll, Wilhelm
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Extension of fundamental mappings
Siberian Mathematical Journal, 1983Translation from Sib. Mat. Zh. 24, No.3(139), 92-101 (Russian) (1983; Zbl 0524.55008).
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A multiclass extension of discriminant mappings
Proceedings., 11th IAPR International Conference on Pattern Recognition. Vol.II. Conference B: Pattern Recognition Methodology and Systems, 2003Multiclass 2-D mapping oriented to classification of multivariate data is discussed. Parametric and nonparametric mapping criteria are used for single level (one shot) projections. A method for reducing the computation complexity of the optimization procedure is suggested. >
Mayer E. Aladjem, Its'hak Dinstein
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ON THE EXTENSION OF EQUIVARIANT MAPPINGS
Mathematics of the USSR-Sbornik, 1975It is proved that a metric space with a homeomorphism of prime period is an equivariant extensor for metric spaces with -dimensional complement if and only if the space itself and the set of fixed points of the homeomorphism are homotopically connected and locally homotopically connected in dimension .Bibliography: 9 titles.
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