Results 31 to 40 of about 1,661,350 (257)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Perceptron-Like Large Margin Classifiers [PDF]
, 2007 We address the problem of binary linear classification with emphasis on algorithms that lead to separation of the data with large margins. We motivate large margin classification from statistical learning theory and review two broad categories of large ...
Tsampouka, Petroula
core +1 more source
Rollover restrictions and firm export behavior: evidence from China
Journal of Applied EconomicsThis paper employs difference-in-differences identification strategy to investigate the impact of nationwide rollover restrictions on firm export behavior with the micro-data of China’s listed firms, using the exogenous event of China passing the ...
Kaihao Liu, Xuefang Wang, Tingru Zhang
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Simple Theory of Economic Development at the Extensive Industry Margin
, 2022 We revisit the well-known fact that richer countries tend to produce a larger variety of goods and analyze economic development through (export) diversifcation.
Diodato, Dario +2 more
core
Firm size and the extensive margin
Economic and Business Review, 2011 <p>In this paper we rely on firm-product-destination level data to analyze Hungarian trade expansion between 1992 and 2003. We decompose trade growth to the number of firms, the number of markets and products per firm, and analyze these dimensions ...
László Halpern, Balázs Muraközy
doaj
East Asian Economic Review, 2012 Previous literature has looked merely into the effect of trade facilitation on aggregate trade, or analyzed trade growth using the extensive and intensive margins.
Hyo-young Lee , Chong-Sup Kim
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Margin requirements with intraday dynamics [PDF]
, 2004 Both in practice and in the academic literature, models for setting margin requirements in futures markets use daily closing price changes. However, financial markets have recently shown high intraday volatility, which could bring more risk than expected.
Cotter, John, Longin, François
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source