Results 41 to 50 of about 1,661,350 (257)
Extensive vs. Intensive Margin in Japan [PDF]
, 2012 This paper studies the role of extensive and intensive margins of labor adjustment over business cycle in Japan. We find that the intensive margin accounts for much of total hours worked variation, and its contribution to the fluctuation of total hours ...
ミヤモト, ヒロアキ +9 more
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Non-homothetic preferences, parallel imports and the extensive margin of international trade [PDF]
, 2010 "We study international trade in a model where consumers have non-homothetic preferences and where household income restricts the extensive margin of consumption. In equilibrium, monopolistic producers set high (low) prices in rich (poor) countries but a
Hepenstrick, Christian +3 more
core +2 more sources
How important is the new goods margin in international trade? [PDF]
We propose a methodology for studying changes in bilateral trade due to countries exporting goods that they did not export previously or exported only in small quantities.
Kim J. Ruhl, Timothy J. Kehoe
core +2 more sources
Frontiers in Environmental ScienceWe quantify the extensive margin of environmental policy—the component of aggregate emissions driven by changes in the number of active firms—in a New Keynesian E-DSGE model with endogenous firm entry, nominal rigidities, and a stock pollutant, estimated
Tian Wu, Ren Wang
doaj +1 more source
An ancient river landscape preserved beneath the East Antarctic Ice Sheet
Nature Communications, 2023 The East Antarctic Ice Sheet (EAIS) has its origins ca. 34 million years ago. Since then, the impact of climate change and past fluctuations in the EAIS margin has been reflected in periods of extensive vs.
Stewart S. R. Jamieson +8 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Agricultural and Resource EconomicsPurpose. This study develops a model to predict and analyse the potential impacts of the Japan-EU Free Trade Agreement (JEFTA) on EU-Japan agri-food trade by focusing on the extensive margin of trade.
Marvin Berndt, Sebastian Hess
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source