Results 61 to 70 of about 3,394,040 (336)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Does climate change exposure affect the intensive and extensive margins of corporate R&D investment?

Quantitative Finance and Economics
In this paper, I investigate how climate change exposure affects extensive and intensive margins of corporate R&D investment. Using firm-level climate change exposure data, the empirical findings indicated that climate change exposure positively and ...
Emmanuel Nkansah
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Extensive margin effects following the Japan-EU free trade agreement: analysing future developments in the agri-food sector

Agricultural and Resource Economics
Purpose. This study develops a model to predict and analyse the potential impacts of the Japan-EU Free Trade Agreement (JEFTA) on EU-Japan agri-food trade by focusing on the extensive margin of trade.
Marvin Berndt, Sebastian Hess
doaj   +1 more source

Practical consensus recommendations for tumor margins and breast conservative surgery

South Asian Journal of Cancer, 2018
My suggestion: There is no difference in survival of breast cancer patients treated with either mastectomy or with breast conservation therapy combined with external beam radiotherapy.
R Sarin, S P Somsekhar, R Kumar, Gupta Pawan, Jain Sumeet, Jindal Pramoj, Zamre Vaishali, Pasha Firoz, P M Parikh, S Aggarwal, R Koul   +10 more
doaj   +1 more source

Deep Large Margin Nearest Neighbor for Gait Recognition

Journal of Intelligent Systems, 2021
Gait recognition in video surveillance is still challenging because the employed gait features are usually affected by many variations. To overcome this difficulty, this paper presents a novel Deep Large Margin Nearest Neighbor (DLMNN) method for gait ...
Xu Wanjiang
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The extensive and intensive effects of Vietnam’s technical measures on agricultural imports

Cogent Economics & Finance
Technical measures, particularly Sanitary and Phytosanitary measures (SPS) and Technical barriers to trade (TBT) can affect to firms’ market entry and the volume of trade.
Bich Ngoc Nguyen
doaj   +1 more source

A formal decomposition of declining youth crime in Denmark

Demographic Research, 2016
Background: Over the recent decades and across most developed democracies, youth crime has been in steady decline, and declining youth crime now constitutes an important contemporary demographic change.
Lars H. Andersen, Anne Sofie Tegner Anker, Signe Hald Andersen   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source