Results 161 to 170 of about 1,611,794 (333)
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Consensus Without Clarity for Dyslexia Identification: A Commentary on Holden et al. [PDF]
Metsala JL +3 more
europepmc +1 more source
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cititul este una din competenţele majore necesare învăţării unei limbi străine. Citirea extensivă este cititul cât mai mult posibil, fără să te gândeşti la minuţiozitatea sensului. Dacă textul este la un nivel corespunzator, cititorul va descoperi că cuvintele necunoscute pot fi descifrate prin examinarea contextului, făcând inutilă utilizarea ...
openaire +1 more source
Studentss Attitudes Towards Extensive and Intensive Reading and Instructorss Motivational Strategies
Inan Deniz Erguvan
openalex +1 more source
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Phonological processing, oral language abilities, and reading comprehension in children with cochlear implants. [PDF]
Camarata S +4 more
europepmc +1 more source

