Results 71 to 80 of about 32,096 (302)
ON COUPLED PROBLEMS FOR VISCOUS FLOW IN EXTERIOR DOMAINS [PDF]
Mathematical Models and Methods in Applied Sciences, 1998 The use of the complete Navier–Stokes system in an unbounded domain is not always convenient in computations and, therefore, the Navier–Stokes problem is often truncated to a bounded domain. In this paper we simulate the interaction between the flow in this domain and the exterior flow with the aid of a coupled problem.
FEISTAUER, M., SCHWAB, C.
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Robin eigenvalue in exterior domains
, 2023 Published by RWTH Aachen University ...
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Electronic Journal of Differential Equations, 2020 In this article we study radial solutions of $\Delta u + K(r)f(u)= 0$ on the exterior of the ball of radius R>0 centered at the origin in ${\mathbb R}^N$ where f is odd with f<0 on $(0, \beta)$, f>$ on $(\beta, \delta)$, $f\equiv 0$ for $u ...
Joseph Iaia
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Positive solutions for semi-linear elliptic equations in exterior domains
Electronic Journal of Differential Equations, 2009 We prove the existence of a solution, decaying to zero at infinity, for the second order differential equation $$ frac{1}{A(t)}(A(t)u'(t))'+phi(t)+f(t,u(t))=0,quad tin (a,infty).
Habib Maagli +2 more
doaj
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Stability and covergence properties of Bergman Kernel methods for numerical conformal mapping [PDF]
, 1984 In this paper we study the stability and convergence properties of Bergman kernel methods, for the numerical conform al mapping of simply and doubly- connected domains.
Warby, M K, Papamichael, N
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