Results 51 to 60 of about 16,079 (267)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
ON COUPLED PROBLEMS FOR VISCOUS FLOW IN EXTERIOR DOMAINS [PDF]
Mathematical Models and Methods in Applied Sciences, 1998 The use of the complete Navier–Stokes system in an unbounded domain is not always convenient in computations and, therefore, the Navier–Stokes problem is often truncated to a bounded domain. In this paper we simulate the interaction between the flow in this domain and the exterior flow with the aid of a coupled problem.
FEISTAUER, M., SCHWAB, C.
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Existence of solutions for semilinear problems on exterior domains
Electronic Journal of Differential Equations, 2020 In this article we prove the existence of an infinite number of radial solutions to $\Delta u+K(r)f(u)=0$ on $\mathbb{R}^{N}$ such that $\lim_{r \to \infty} u(r)=0$ with prescribed number of zeros on the exterior of the ball of radius R>0 where f ...
Joseph Iaia
doaj
The Robin eigenvalue in exterior domains
, 2023 Published by RWTH Aachen University ...
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Critical Neumann problem for nonlinear elliptic systems in exterior domains
Electronic Journal of Differential Equations, 2008 In this paper, we investigate the Neumann problem for a critical elliptic system in exterior domains. Assuming that the coefficient $Q(x)$ is a positive smooth function and $lambda$, $mugeq0$ are parameters, we examine the common effect of the mean ...
Jianfu Yang, Shengbing Deng
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source