Results 51 to 60 of about 1,283,435 (290)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Existence of solutions for semilinear problems with prescribed number of zeros on exterior domains

Electronic Journal of Differential Equations, 2016
In this article we prove the existence of an infinite number of radial solutions of $\Delta(u)+f(u)=0$ with prescribed number of zeros on the exterior of the ball of radius R>0 centered at the origin in $\mathbb {R}^N$ where f is odd with f0 on ...
Janak Joshi, Joseph Iaia
doaj  

A Nonlinear Parabolic Problem in an Exterior Domain

Journal of Differential Equations, 1998
The author considers the parabolic differential equation \(u_t -\Delta u +u^p=0\) in the exterior of a bounded domain with finitely many components, each having a smooth boundary. Zero Dirichlet data is prescribed along with an initial function \(u_0\) such that \[ \lim_{| x| \to\infty} \frac {u^0(x)}{A| x| ^{-\alpha}} = 1 \] for some positive ...
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Discrete exterior geometry approach to structure-preserving discretization of distributed-parameter port-Hamiltonian systems [PDF]

, 2011
This paper addresses the issue of structure-preserving discretization of open distributed-parameter systems with Hamiltonian dynamics. Employing the formalism of discrete exterior calculus, we introduce a simplicial Dirac structure as a discrete analogue
Seslija, Marko,, Scherpen, Jacquelien M.A.,, van der Schaft, Abraham, van der Schaft, Abraham; id_orcid, Arjan Van Der Schaft, Jacquelien M. A. Scherpen, van der Schaft, Arjan, Scherpen, Jacquelien M.A., Seslija, Marko, van der Schaft, Arjan ; id_orcid, Marko Seslija, Schaft, Arjan van der,   +11 more
core   +3 more sources

Blow-Up Results for Higher-Order Evolution Differential Inequalities in Exterior Domains

Advanced Nonlinear Studies, 2019
We consider a higher-order evolution differential inequality in an exterior domain of ℝN{\mathbb{R}^{N}}, N≥3{N\geq 3}, with Dirichlet and Neumann boundary conditions.
Jleli Mohamed, Kirane Mokhtar, Samet Bessem   +2 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

La restricción exterior al crecimiento económico español (1870-1913) [PDF]

, 1996
Editada en la Fundación Empresa PúblicaEn este artículo se realiza una estimación de las funciones de largo plazo del comercio exterior español en los años que van de 1870 a 1913.
Herranz Loncán, Alfonso, Tirado, Daniel A.   +1 more
core   +2 more sources

Some remarks on Riesz transforms on exterior Lipschitz domains

Forum of Mathematics, Sigma
Let $n\ge 2$ and $\mathcal {L}=-\mathrm {div}(A\nabla \cdot )$ be an elliptic operator on $\mathbb {R}^n$ . Given an exterior Lipschitz domain $\Omega $ , let $\mathcal {L}_D$ be the elliptic operator $\mathcal {L}$
Renjin Jiang, Sibei Yang
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source