Results 111 to 120 of about 2,620,097 (300)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Acidentes de trânsito no Brasil: dados e tendências

Cadernos de Saúde Pública
As estatísticas de mortalidade mostram, em 1988, para o Brasil, que cerca de 12% dos óbitos são devidos a causas externas, e destes 30% são por acidentes de trânsito. Quando se comparam com outros países, os dados referentes ao Brasil são sempre elevados.
Maria Helena P. de Mello Jorge, Maria Rosário D. O. Latorre   +1 more
doaj  

Mortalidad por causas accidentales en niños menores de 5 años en el Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera", 2002-2004 Mortality due to accidental causes in children younger than 5 years of age at the Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera", 2002-2004

Acta Médica Costarricense, 2008
Las lesiones traumáticas por causas externas corresponden en Costa Rica a la segunda causa de muerte en niños menores de 5 años, con una tasa para 2004 de 9.23 x 100000 habitantes, y la primera causa de años de vida potencialmente perdidos (37%) para ...
Adriana Benavides-Lara, Marco Vargas-Salas   +1 more
doaj  

Infant mortality in Brazil from 2000 to 2020: a study of spatial and trend analysis

BMC Public Health
Background The Infant Mortality Rate assesses the deaths occurring in children under one year of age and serves as an important health indicator in mapping the living conditions of a given society.
Tainara Lorena dos Santos Ferreira, Ketyllem Tayanne da Silva Costa, Richardson Augusto Rosendo da Silva, Angelo Giuseppe Roncalli da Costa Oliveira, Fábia Barbosa de Andrade   +4 more
doaj   +1 more source

Childhood adversity is associated with hospitalisations and survival following external causes and non-communicable diseases: a 46-year follow-up of a Stockholm birth cohort. [PDF]

J Epidemiol Community Health, 2023
Jackisch J, Almquist YB.
europepmc   +1 more source

External Causes of Illness [PDF]

, 2021
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Ambient Temperature and External Causes of Death in Japan from 1979 to 2015: A Time-Stratified Case-Crossover Analysis. [PDF]

Environ Health Perspect, 2022
Pan R, Honda Y, Minakuchi E, Kim SE, Hashizume M, Kim Y.   +5 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

International classification of external causes of injury: a study on its content coverage. [PDF]

BMC Med Inform Decis Mak, 2021
Ahmadian L, Salehi F, Padidar S.
europepmc   +1 more source