Results 51 to 60 of about 2,620,097 (300)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Trends in hospitalizations due to motorcycle accidents involving men aged 20 to 39 years in the state of Santa Catarina - Southern Brazil

Cadernos de Saúde Coletiva, 2017
Introduction Motorcycles accidents are responsible for most of the injuries due to external causes and consequent high hospitalization rates. Objective This study aimed to analyze the temporal trend in motorcycle accident morbidity among young male ...
Ione Jayce Ceola Schneider, Marcelo Vargas Schütz, Nazaré Otília Nazário, Ameg Dalpiaz, Alexandre Márcio Marcolino, Rafael Inácio Barbosa   +5 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Coherence-preserving trap architecture for long-term control of giant Rydberg atoms

, 2004
We present a way to trap a single Rydberg atom, make it long-lived and preserve an internal coherence over time scales reaching into the minute range. We propose to trap using carefully designed electric fields, to inhibit the spontaneous emission in a ...
Brune, Michel, Haroche, Serge, Hyafil, Philippe, Mozley, John, Nogues, Gilles, Perrin, Aurelien, Raimond, Jean-Michel, Tailleur, Julien   +7 more
core   +1 more source

A variable neurodegenerative phenotype with polymerase gamma mutation [PDF]

, 2009
mtDNA replication and repair, causes mitochondrial diseases including autosomal dominant progressive external ophthalmoplegia (PEO),1 childhood hepato-encephalopathy (Alpers– Huttenlocher syndrome), adult-onset spinocerebellar ataxia, and sensory nerve
Baruffini, E., Endres, M., Horvath, Rita, Lodi, T., Meisel, A., Prüss, H., Siebert, E., Stricker, S., Zschenderlein, R.   +8 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Informações sobre causas externas em internações hospitalares: conhecimento e opiniões de médicos auditores após uma intervenção = Information about external causes in hospitalization records: medical auditors knowledge and opinions after an intervention [PDF]

Acta Scientiarum. Health Sciences, 2012
Objetivou-se avaliar o conhecimento de médicos auditores, participantes ou não de uma intervenção aplicada em Londrina, Estado do Paraná, para melhorar a codificação do diagnóstico principal e secundário de causas externas de internação, e identificar ...
Selma Maffei de Andrade, Hellen Geremias dos Santos, Marcela Maria Birolim   +2 more
doaj  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source