Results 81 to 90 of about 2,635,035 (294)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Fall-related traumas in urgent care centers
Clinics, 2012 OBJECTIVE: To identify the scope and the characteristics of fall-related traumas in urgent care centers in Sergipe, Brazil and to verify potential associations among the following variables: gender, age, and where the event occurred.
Carla Kalline Alves Cartaxo +4 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Validação de variáveis de declarações de óbito por causas externas, Recife, PE, Brasil
Revista de Saúde PúblicaOBJETIVOS: Validar, nas declarações de óbitos por causas externas de menores de 20 anos residentes no Recife em 1995, outras variáveis que não a causa básica dos óbitos.
Maria Dilma de A Barros +2 more
doaj
Russian mortality beyond vital statistics [PDF]
Analyses of routine data have established that the extreme mortality fluctuations among young and middle-aged men are the most important single component of both temporal changes in Russian life expectancy at birth and in the gap between male and female ...
FFF1Vladimir NNN1Shkolnikov +3 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Revista Brasileira de Saúde OcupacionalRESUMO OBJETIVO: caracterizar os acidentes de trabalho fatais e analisar a qualidade das informações de seus registros. MÉTODO: estudo ecológico com análise descritiva dos óbitos por acidentes de trabalho no Brasil, em Minas Gerais e no município de ...
Helena Hemiko Iwamoto +3 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Adequacy of Data on Injuries’ External Causes for Coding Based on ICD-10 in Inpatient Medical Records and Emergency Wards of Shahid Beheshti Hospital in Kashan [PDF]
پیاورد سلامت, 2012 Background and Aim: Knowledge about the external causes of accidents is vital for their prevention, and insufficient data on external causes can reduce their usefulness. That is why, the adequacy of the sources of data is of great importance.
Fatemeh Rangraz Jeddi +2 more
doaj
Employment Flows with Endogenous Financing Constraints [PDF]
Empirical studies document that resource reallocation across production units plays an important role in accounting for aggregate productivity growth in the U.S. manufacturing.
Shuyun May Li
core