Results 51 to 60 of about 400,488 (346)

External fixation in the treatment of open tibial shaft fractures [PDF]

, 2008
Background/Aim. Besides the conquasant fractures, open tibia shaft fractures belong to the group of the most severe fractures of tibia. Open tibia shaft fracture is one of the most common open fractures of long bones.
Golubović Ivan, Golubović Zoran, Kadija Marko, Matović Zoran, Mačukanović-Golubović Lana, Milenković Saša, Milić Dragan, Mitković Milorad, Radenković Mile, Stojanović Saša, Stojiljković Predrag, Turković Goran, Vidić Goran, Višnjić Aleksandar   +13 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

EXTERNAL FIXATOR;

The Professional Medical Journal, 2013
Introduction: Open Tibial shaft fractures are one of the most common fractures of long bones. External fixation is methodof choice for the treatment of open tibial shaft fractures. The subcutaneous location of tibia makes it suitable for the application of externalfixator.
ROOHULLAH JAN, ZAHID ASKAR, JAVED IQBAL
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Single-stage management of Charcot neuroarthropathy and osteomyelitis in diabetic patients

Journal of the Foot & Ankle
Objective: Describe our experience treating Charcot neuroarthropathy (CN) coexisting with concurrent bone infection in a single step, treated with external fixation, and report the mid-term radiographic and functional outcomes.
gonzalo alvarez, Juan Pablo Randolino, Emanuel David Gonzalez, Laura Gaitan, Valeria Lopez   +4 more
doaj   +1 more source

A novel fixation method for panfacial fracture using an Ilizarov-type external fixator

Trauma Case Reports, 2019
In general, internal plate fixation is mainly performed in order to reduce multiple facial bone fractures and rarely uses an external fixator. Although it would be ideal to successfully achieve or preserve the occlusal relationship of the upper and lower
Masakatsu Hihara, Takuma Yagura, Masayasu Takegawa, Natsuko Kakudo, Naoki Morimoto, Kenji Kusumoto   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Factors influencing self-care in outpatients with external fixation in China

Journal of International Medical Research, 2020
Objective This study was performed to investigate factors influencing self-care agency in outpatients with external fixation support. Methods Using a cross-sectional study approach, 110 outpatients with external fixation from a single Chinese hospital ...
Jun Xing, Ning Sun, Laiyou Li, Dongmei Lv, Shuling Geng, Yuqian Li   +5 more
doaj   +1 more source

Combined Internal and External Fixation for Charcot Neuro Arthropathy: 1 Year Results

Foot & Ankle Orthopaedics, 2022
Category: Diabetes Introduction/Purpose: Complex foot and ankle deformities secondary to charcot neuroarthropathy continue to represent a significant challenge and management quandary.
Muhammed H. Iqbal MD, Sultan N. Qasim FRCS(Tr&Orth), Simon Chambers FRCS   +2 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source