Results 61 to 70 of about 400,488 (346)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Osteosíntesis externa: Rigidez y Elasticidad [PDF]
, 1990 Los autores revisan la experiencia acumulada en el tratamiento de fracturas abiertas de tibia y peroné con atricción de partes blandas correspondientes a los grados II y III de CAUCHOIX.
Albert Cortel, L. +2 more
core
Fast and asymptotic computation of the fixation probability for Moran processes on graphs [PDF]
, 2015 Evolutionary dynamics has been classically studied for homogeneous populations, but now there is a growing interest in the non-homogenous case. One of the most important models has been proposed by Lieberman, Hauert and Nowak, adapting to a weighted ...
Cuesta, Fernando Alcalde +2 more
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
THE TREATMENT OF OPEN & CLOSED TIBIAL FRACTURES BY PRIMARY EXTERNAL FIXATION & BONE GRAFT [PDF]
Basrah Journal of Surgery, 2005 We prospectively studied 64 patients with fracture shaft tibia, 23 patients with closed tibial fracture and 41 patients with open type. All fractures were stabilized by external fixation device AO/ASIF type after failed manipulation under anesthesia
Mohammad S Al-Edany, Thamer A Hamdan
doaj +1 more source
Comparison of a reverse-transverse cross pin technique with a same side cross pin type II external skeletal fixator in 89 dogs [PDF]
, 2015 The objective of this study was to determine whether a novel reverse-transverse cross pin insertion technique could increase the stability of type II external skeletal fixators (ESF) in dogs compared with an alternate, same side cross pin ESF.
Pead, M J, Tsai, K-Y
core
The Outer Tracker Detector of the HERA-B Experiment Part I: Detector [PDF]
, 2005 The HERA-B Outer Tracker is a large system of planar drift chambers with about 113000 read-out channels. Its inner part has been designed to be exposed to a particle flux of up to 2.10^5 cm^-2 s^-1, thus coping with conditions similar to those expected ...
A. Donat +83 more
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
A New Type of External Fixation
Engineering Transactions, 2015 The paper presents some problems related to external osteosynthesis. Design of the new generation of external fixators should use modelling, computer simulation and clinical postulates.
D. Jasińska-Choromańska +1 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source