Results 81 to 90 of about 3,220,539 (261)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

An oral microbiota-based deep neural network model for risk stratification and prognosis prediction in gastric cancer

Journal of Oral Microbiology
Background This study aims to develop an oral microbiota-based model for gastric cancer (GC) risk stratification and prognosis prediction.Methods Oral microbial markers for GC prognosis and risk stratification were identified from 99 GC patients, and ...
Xue-Feng Gao, Can-Gui Zhang, Kun Huang, Xiao-Lin Zhao, Ying-Qiao Liu, Zi-Kai Wang, Rong-Rong Ren, Geng-Hui Mai, Ke-Ren Yang, Ye Chen   +9 more
doaj   +1 more source

Lactic Acidosis Interferes With Toxicity of Perifosine to Colorectal Cancer Spheroids: Multimodal Imaging Analysis

Frontiers in Oncology, 2020
Colorectal cancer (CRC) is a disease with constantly increasing incidence and high mortality. The treatment efficacy could be curtailed by drug resistance resulting from poor drug penetration into tumor tissue and the tumor-specific microenvironment ...
Barbora Pavlatovská, Markéta Machálková, Petra Brisudová, Adam Pruška, Karel Štěpka, Jan Michálek, Tereza Nečasová, Petr Beneš, Petr Beneš, Jan Šmarda, Jan Preisler, Michal Kozubek, Jarmila Navrátilová, Jarmila Navrátilová   +13 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Embryonic Development of Pediculus humanus capitis: Morphological Update and Proposal of New External Markers for the Differentiation Between Early, Medium, and Late Eggs. [PDF]

Acta Parasitol, 2023
Álvarez-Fernández BE, Valero MA, Nogueda-Torres B, Morales-Suárez-Varela MM.   +3 more
europepmc   +1 more source

Household external finance and consumption

, 2008
This paper uses mortgage data to construct a measure of terms on which households access to external finance, and relates it to consumption at both the aggregate and cohort levels. The Household External Finance (HEF) index is based on the spread paid by
Meads, Neil, Surico, Paolo, Besley, Timothy   +2 more
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Methodology on Co-Registration of MRI and Optoelectronic Motion Capture Marker Sets: In-Vivo Wrist Case Study

Hittite Journal of Science and Engineering, 2019
S kin-surface mounted markers provide incomplete spatial information of the underlying-bone. A new methodology is developed combining optoelectronic motion capture MOCAP and imaging modalities to co-register the positions of underlying-bone and ...
Senay Mihcin
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source