Results 81 to 90 of about 570,966 (263)

Long-Term Dynamic Monitoring of Post-Tensioning External Tendons: Temperature Effect Evaluation

Buildings
Cables and tendons are crucial elements in bridge engineering but also are vulnerable structural elements because they are usually subjected to fatigue and corrosion problems.
Luis Chillitupa-Palomino, Carlos M. C. Renedo, Jaime H. García-Palacios, Iván M. Díaz   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Influence of Weekly Training Load on Match Physical Demands in Spanish Professional Soccer Players: A Full In-Season Study

Sensors
This study aimed (i) to analyze the relationship between weekly accumulated training load (TL) and match physical demands in the same week and (ii) to describe the training/match ratios of different external load measures considering variations across ...
José C. Ponce-Bordón, Jorge Polo-Tejada, David Lobo-Triviño, Borja Sanabria-Pino, Javier Raya-González, Alberto Muñoz, Tomás García-Calvo   +6 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Unraveling athletic performance: Transcriptomics and external load monitoring in handball competition.

PLoS ONE
ObjectiveThis study aims to comprehend the impact of handball practice on sub-elite athletes by investigating transcriptomic changes that occur during a match.
Pol Ezquerra Condeminas, Milos Mallol, Roger Font, Victor Tremps, Jose Antonio Gutiérrez, Gil Rodas, Alexandre Perera Lluna, José Manuel Soria   +7 more
doaj   +3 more sources

Exploring the Relationship Between Game Performance and Physical Demands in Youth Male Basketball Players

Journal of Functional Morphology and Kinesiology
Background: Understanding the relationship between physical demands and game performance is essential to optimize player development and management in basketball.
Javier Espasa-Labrador, Carlos Martínez-Rubio, Franc García, Azahara Fort-Vanmeergaehe, Jordi Guarch, Julio Calleja-González   +5 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

EXTERNAL AND INTERNAL SOURCE MONITORING: META-ANALYSIS OF FMRI STUDIES

IBRO Neuroscience Reports, 2023
Beatriz Martin Luengo, Aleksandra Dolgoarshinnaia, Oksana Zinchenko   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source