Results 61 to 70 of about 569,600 (263)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Evaluation of dermal exposure to 5-Fluorouracile in a healthcare setting

Safety and Health at Work, 2022
Matteo Creta, Birgit Tans, Herman Devriese, Lode Godderis, Radu Corneliu Duca, Jeroen Vanoirbeek   +5 more
doaj   +1 more source

National Independent Monitoring Mechanisms for Fundamental Rights Compliance at the EU’s External Borders

European Papers
(Series Information) European Papers - A Journal on Law and Integration, 2024 9(3), 1216-1227 | Article | (Table of Contents) I. Introduction – II. Croatian experience with its national independent monitoring mechanism – III.
Iris Goldner Lang
doaj   +1 more source

External evaluation and self-monitoring of the Baby-friendly Hospital Initiative’s maternity hospitals in Brazil

International Breastfeeding Journal, 2019
Background In Brazil, the Baby-Friendly Hospital Initiative (BFHI) proposes following the criteria, the “Ten Steps to Successful Breastfeeding”, International Code of Marketing of Breast-milk Substitutes and Good birth and delivery practices.
Renara Guedes Araújo, Vânia de Matos Fonseca, Maria Inês Couto de Oliveira, Eloane Gonçalves Ramos   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Monitoring external and internal training and match loads in professional soccer players during excessive heat stress

Human Movement
Purpose This study explored how heat stress affects training and match load in professional soccer by monitoring ten elite players during sessions under normal (18–24°C) and high (34–45°C) temperatures.
Alireza Rabbani, Filipe Manuel Clemente, Željko Banićević, Ivana Banićević, Rui Miguel Silva   +4 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

The Influence of Seasonal Period and Match Outcome on External Load in Professional Soccer Players: Analyzing the Effect of Winning and Losing Streaks

Sensors
The aim of this study was threefold: (i) to analyze the influence of previous match outcome on subsequent weekly training load (TL); (ii) to examine whether accumulated weekly TL varies throughout the season; and (iii) to investigate the influence of ...
José C. Ponce-Bordón, Jorge Polo-Tejada, David Lobo-Triviño, Borja Sanabria-Pino, Javier Raya-González, Alberto Muñoz, Tomás García-Calvo   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source