Results 31 to 40 of about 675,948 (263)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Internal Initiative vs External Pressure: Evidence from Halal Standard Adoption in Indonesian Food Small and Medium Industries (SMIs)

Indonesian Journal of Halal Research
This research's focal points are identifying key factors of halal food standards (HFS) in small-medium industries (SMIs) in Padang and exploring the roles of traceability systems in compliance with the halal assurance system (HAS).
Nilda Tri Putri, Meuthia Meuthia, Ikhsan Rapi Saputra, Rini Rahmahdian S, Iwan Vanany, Norhayati Zakuan   +5 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Buckling Behavior of Stainless Wave-Shaped Pressure Hulls

Journal of Marine Science and Engineering
This study primarily focuses on the buckling behavior of wave-shaped pressure hulls subjected to uniform external pressure. The effect of slant angle on the buckling behavior of hulls was examined.
Lingtong Zheng, Yunsen Hu, Huifeng Jiao, Jian Zhang   +3 more
doaj   +1 more source

FAKTOR-FAKTOR YANG MEMPENGARUHI KECENDERUNGAN KECURANGAN LAPORAN KEUANGAN PADA PERUSAHAAN PROPERTY, REAL ESTATE AND BUILDING YANG TERDAFTAR DI BEI TAHUN 2013-2015

Jurnal Akuntansi Kontemporer, 2020
This study aimed to analyze the factors that influence the tendency of fraudulent financial statement with analysis of the fraud triangle. The samples used by the company of property, real estate and building construction which listed at Indonesia Stock ...
Elysabet Christy Diandra Selano, Budianto Tedjasuksmana, Rr. Puruwita Wardani   +2 more
doaj   +1 more source

Effects of external temperature and dead volume on laboratory measurements of pore pressure and injected volume in a rock fracture

Journal of Rock Mechanics and Geotechnical Engineering, 2022
The accurate evaluation of pore pressure and injected volume is crucial for the laboratory characterization of hydromechanical responses of rock fractures. This study reports a series of laboratory experiments to systematically demonstrate the effects of
Yinlin Ji, Christian Kluge, Hannes Hofmann, Guido Blöcher   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Assessment of Buckling Failure in Oil Storage Tanks: Finite Element Simulation of Combined Internal and External Pressure Scenarios

Science, Engineering and Technology
Investigating the structural behaviour and buckling susceptibility of cylindrical oil storage tanks is crucial for ensuring their safe and reliable operation.
Themba Mashiyane, Lagouge Tartibu, Smith Salifu   +2 more
doaj   +1 more source