Results 51 to 60 of about 482,434 (309)

METHODOLOGICAL APPROACHES TO ESTIMATING OF PROFESSIONAL COMPETENCE OF LABORATORY SPECIALISTS AT MEDICAL AND PREVENTIVE ORGANIZATIONS AND THE FEDERAL SERVICE FOR SUPERVISION OF CONSUMER PROTECTION AND WELFARE (ROSPOTREBNADZOR) FOR MICROSCOPIC DETECTION OF AGENTS OF ZOONOTIC HELMINTHOSIS IN BIOLOGICAL MATERIAL

Российский паразитологический журнал, 2016
Based on the results of microscopic detection of zoonotic agents using virtualization preparations of distance education technologies the laboratory specialists of medical and preventive organizations of the Ministry of Health of the RF and Centers for ...
A. S. DOVGALYOV, S. Yu. ASTANINA, A. P. SERDYUK, N. D. ANDREEVA, G. Yu. NIKITINA   +4 more
doaj  

Building Quality Control for Molecular Assays in the Global Measles and Rubella Laboratory Network

Vaccines
More than 100 laboratories in the World Health Organization Global Measles and Rubella Laboratory Network (GMRLN) perform nucleic acid-based methods for case confirmation of measles or rubella infections and/or strain surveillance (genotyping).
Bettina Bankamp, Raydel Anderson, Lijuan Hao, Elena Lopareva, Min-hsin Chen, Gimin Kim, R. Suzanne Beard, Yoshio Mori, Noriyuki Otsuki, Akihido Ryo, Paul A. Rota   +10 more
doaj   +1 more source

External quality assessment of dengue and chikungunya diagnostics in the Asia Pacific region, 2015

Western Pacific Surveillance and Response, 2016
Objective: To conduct an external quality assessment (EQA) of dengue and chikungunya diagnostics among national-level public health laboratories in the Asia Pacific region following the first round of EQA for dengue diagnostics in 2013.
Li Ting Soh, Raynal C Squires, Li Kiang Tan, Kwoon Yong Pok, HuiTing Yang, Christina Liew, Aparna Singh Shah, John Aaskov, Sazaly Abubakar, Futoshi Hasabe, Lee Ching Ng, Frank Konings   +11 more
doaj   +1 more source

NGS-Based S. aureus Typing and Outbreak Analysis in Clinical Microbiology Laboratories: Lessons Learned From a Swiss-Wide Proficiency Test

Frontiers in Microbiology, 2020
Whole genome sequencing (WGS) enables high resolution typing of bacteria up to the single nucleotide polymorphism (SNP) level. WGS is used in clinical microbiology laboratories for infection control, molecular surveillance and outbreak analyses.
David Dylus, David Dylus, David Dylus, Trestan Pillonel, Onya Opota, Daniel Wüthrich, Daniel Wüthrich, Helena M. B. Seth-Smith, Helena M. B. Seth-Smith, Adrian Egli, Adrian Egli, Stefano Leo, Vladimir Lazarevic, Jacques Schrenzel, Sacha Laurent, Claire Bertelli, Dominique S. Blanc, Stefan Neuenschwander, Alban Ramette, Laurent Falquet, Laurent Falquet, Frank Imkamp, Peter M. Keller, Andre Kahles, Andre Kahles, Simone Oberhaensli, Simone Oberhaensli, Valérie Barbié, Christophe Dessimoz, Christophe Dessimoz, Christophe Dessimoz, Christophe Dessimoz, Christophe Dessimoz, Gilbert Greub, Aitana Lebrand   +34 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

First round of external quality assessment of dengue diagnostics in the WHO Western Pacific Region, 2013

Western Pacific Surveillance and Response, 2015
Objective: Accurate laboratory testing is a critical component of dengue surveillance and control. The objective of this programme was to assess dengue diagnostic proficiency among national-level public health laboratories in the World Health ...
Kwoon Yong Pok, Raynal C Squires, Li Kiang Tan, Tomohiko Takasaki, Sazaly Abubakar, Futoshi Hasebe, Jeffrey Partridge, Chin Kei Lee, Janice Lo, John Aaskov, Lee Ching Ng, Frank Konings   +11 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Dry Panels Supporting External Quality Assessment Programs for Next Generation Sequencing-Based HIV Drug Resistance Testing

Viruses, 2020
External quality assessment (EQA) is a keystone element in the validation and implementation of next generation sequencing (NGS)-based HIV drug resistance testing (DRT). Software validation and evaluation is a critical element in NGS EQA programs.
Marc Noguera-Julian, Emma R. Lee, Robert W. Shafer, Rami Kantor, Hezhao Ji   +4 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

National Program for External Quality Assessment of Chinese Newborn Screening Laboratories

International Journal of Neonatal Screening, 2020
Objectives: To analyze the coefficient of variation (CV) of external quality assessment (EQA) in Chinese newborn screening (NBS) laboratories. Method: EQA’s robust CV was analyzed by the Clinet-EQA evaluation system.
Yuxuan Du, Wei Wang, Jiali Liu, Zhixin Zhang, Zhen Zhao, Falin He, Shuai Yuan, Zhiguo Wang   +7 more
doaj   +1 more source