Results 61 to 70 of about 3,456 (189)

Interlaboratory performance testing on EPIC v2.0 CNS tumor profiling demonstrates high reproducibility of tumor classification but reveals the need for harmonized copy number variation reporting

Brain Pathology, EarlyView.
Using the Infinium MethylationEPIC v2.0 array and Heidelberg Brain Tumor Classifier v12.8, 24 international laboratories achieved highly reproducible CNS tumor classification (97.9% correct; median β‐correlation r = 0.99), while copy number variation interpretation showed substantial interlaboratory variability, highlighting the need for harmonized CNV
Katrin Mauch‐Mücke, Christin Siewert, Lora Dimitrova, Sandra Pohl, Brendan Osberg, Annika K. Wefers, Julia Lorenz, Tanja Rothhammer‐Hampl, Till Acker, Alonso Barrantes‐Freer, Jean Boutonnat, Bérengère Dadone‐Montaudié, Claire Delbridge, Wolfgang Dietmaier, Sebastian Dintner, Hildegard Dohmen, Matthias Dottermusch, Daniel Erny, Katrin B. M. Frauenknecht, Tobias Goschzik, Patrick N. Harter, Daniela Hirsch, Yanghao Hou, Theo F. J. Kraus, Maggie Lee, Friederike Liesche‐Starnecker, Anne Mc Leer, Linea Melchior, Michael Mittelbronn, Wolf C. Müller, Shalima S. Nair, Julia E. Neumann, Pitt Niehusmann, Nicole Pfarr, Torsten Pietsch, Marco Prinz, Markus Rechsteiner, Regina Reimann, Laveniya Satgunaseelan, Veronica Skarpeteig, Anne J. Skjulsvik, Karl Sotlar, Isabelle Vanden Bempt, Erik Vassella, Katharina J. Weber, Gabriel Wasinger, Andreas Waha, Karen Zwaenepoel, Felix Sahm, Markus J. Riemenschneider, David Capper   +50 more
wiley   +1 more source

Evaluation of the diagnostic capacities for emerging arboviral diseases in the international network MediLabSecure from 2014 to 2018 - Importance of external quality assessments

Journal of Infection and Public Health, 2022
Background: Emerging infectious diseases pose an increasing threat to all nations around the world, including to developed countries. By definition, because they are rare or unknown, public health systems are not well prepared against these emerging ...
Guillain Mikaty, Séverine Matheus, Oliver Donoso Mantke, Elaine McCulloch, Heinz Zeichhardt, Jean-Claude Manuguerra, Jean-Claude Manuguerra   +6 more
doaj   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

Interpretation of EQA results and EQA-based trouble shooting [PDF]

, 2017
Important objectives of External Quality Assessment (EQA) is to detect analytical errors and make corrective actions. The aim of this paper is to describe knowledge required to interpret EQA results and present a structured approach on how to handle ...
Gunn Berit Berge Kristensen, Piet Meijer, Berge Kristensen, Gunn Berit, Meijer, Piet   +3 more
core   +2 more sources

UK recommendations for Ki‐67 immunohistochemical staining and interpretation in breast cancer

Histopathology, EarlyView.
Where possible, a validated digital imaging system should be utilized. If this is not available, then intermediate scores (5%–30%) should be thoroughly assessed using the Ki‐67 International Working Group guidance. Difficult cases should be double scored.
Abeer M Shaaban, Andrew Dodson, Emad Rakha, Ian Ellis, Daniel Rea, Cecily Quinn, Elena Provenzano, Sarah Pinder, on behalf of the UK National Coordinating Committee for Breast Pathology (NCCBP), Association of Breast Pathology (ABP) and the UK National External Quality Assessment Scheme for Immunohistochemistry and In Situ Hybridisation (UK NEQAS ICC & ISH)   +9 more
wiley   +1 more source

Exploration of evaluation criteria based on the biological variation in the external quality assessment for basic semen analysis in China

Asian Journal of Andrology
This study explores whether the current external quality assessment (EQA) level and acceptable bias for basic semen analysis in China are clinically useful.
Xi-Yan Wu, Jin-Chun Lu, Xin-Hua Peng, Jing-Liang He, Dao Wang, Cong-Ling Dai, Wen-Bing Zhu, Gang Liu, Wei-Na Li   +8 more
doaj   +1 more source

Different Analytical Modes on Automatic Hematology Analyzers for Testing Quality Control Materials and Commutability Assessment

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Hematological disorders, critical for diagnosis, and monitoring, rely on accurate complete blood count results from automated analyzers, the reliability of which depends on robust quality control (QC). However, the ability of commutability of commercial hematology QC materials (HQCM) to behave like patient samples across different
Bingshuang Ren, Ya Cheng, Hongping Ba, Weijia Cheng, Xuwei Zhou, Hui Zhen, Shimin Wu, Jie Gong   +7 more
wiley   +1 more source

Testing for Non‐Severe Heritable Platelet Function Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Heritable platelet function disorders (HPFD) are a diverse group of bleeding disorders characterised by a primary qualitative defect in platelet function rather than platelet number. HPFD may be broadly categorised according to the severity of bleeding, with Glanzmann thrombasthenia and Bernard Soulier syndrome classically considered severe ...
Kate Burley, Naomi Cornish, Maria Molina Carretero, Sarah K. Westbury   +3 more
wiley   +1 more source

Nationwide External Quality Assessment of SARS-CoV-2 Molecular Testing, South Korea

Emerging Infectious Diseases, 2020
External quality assessment (EQA) is essential for ensuring reliable test results, especially when laboratories are using assays authorized for emergency use for newly emerging pathogens.
Heungsup Sung, Myung-Guk Han, Cheon-Kwon Yoo, Sang-Won Lee, Yoon-Seok Chung, Jae-Sun Park, Mi-Na Kim, Hyukmin Lee, Ki Ho Hong, Moon-Woo Seong, Kyunghoon Lee, Sail Chun, Wee Gyo Lee, Gye-Cheol Kwon, Won-Ki Min   +14 more
doaj   +1 more source

Comparability of thyroid-stimulating hormone immunoassays using fresh frozen human sera and external quality assessment data.

PLoS ONE, 2021
BackgroundThis study aimed to assess the comparability among assays using freshly frozen human sera and external quality assessment (EQA) data in China.MethodsTwenty-nine serum samples and two commercial EQA materials, obtained from the National Center ...
Shunli Zhang, Fei Cheng, Hua Wang, Jiangping Wen, Jie Zeng, Chuanbao Zhang, Wensong Liu, Ning Wang, Tingting Jia, Mo Wang, Rui Zhang, Yuhong Yue, Jing Xu, Zhanyong Wang, Yilong Li, Wenxiang Chen, Qingtao Wang   +16 more
doaj   +1 more source