Results 51 to 60 of about 2,961,144 (192)

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

Model‐Driven Monitoring and Parameter‐Based Development of an Escherichia coli Fed‐Batch Process for Production of a Fab Antibody Fragment Across Scales

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg, Lucas Kaspersetz, Markus Zoellkau, Markus Glaser, Markus Brunner, Christian Bosch, Annina Kemmer, M. Nicolas Cruz Bournazou, Peter Neubauer   +8 more
wiley   +1 more source

Experimental Investigation on CHF along Elliptic-shaped Lower Head Wall and Influencing Factor under IVR-ERVC Condition

Yuanzineng kexue jishu, 2022
External reactor vessel cooling (ERVC) is one of the important severe accident mitigation strategies to achieve in-vessel retention(IVR) of melt core debris under severe accident conditions.
HE Yihai;WANG Gang;KUANG Bo;LUO Yuejian;WU Xiaoli
doaj  

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

In-depth investigation of natural convection thermal characteristics of BALI experiment through Eulerian computational fluid dynamics code and comparison with Lagrangian code

Nuclear Engineering and Technology
In-vessel retention through external reactor vessel cooling (IVR-ERVC) is a severe accident management (SAM) strategy that has been adopted and used in many nuclear reactors such as AP1000, APR1400, and light water reactor etc.
Hyeongi Moon, Sohyun Park, Eungsoo Kim, Jae-Ho Jeong   +3 more
doaj   +1 more source

Beyond Furnaces: Harnessing In Situ Joule Heating for Efficient C1 Catalysis

Carbon Energy, EarlyView.
Joule‐heated catalysis directly converts electrical energy into localized heat within conductive catalysts, overcoming the heat‐transfer limitations of conventional furnaces. This review summarizes recent advances in C1 molecule conversion, including CO2 methanation, reforming for hydrogen production, and HCHO/CO oxidation, while highlighting ...
Xue Kong, Tiantian Su, Faiza Meharban, Shengbin Cao, Jingsan Xu, Chao Lin, Xiaopeng Li, Yejian Xue, Wei Luo   +8 more
wiley   +1 more source

Different Heat Transfer Modes of Heavy Metallic Layer in IVR Strategy

Yuanzineng kexue jishu, 2022
There might be a three-layer molten pool configuration with a heavy metallic layer at the bottom in the stratified molten pool configuration. Because of the decay heat in the heavy metallic layer and the relatively low critical heat flux (CHF) at the ...
LI Zongyang;CHANG Huajian;CHEN Lian;HAN Kun;FANG Fangfang
doaj  

Investigation of vessel exterior air cooling for a HLMC reactor [PDF]

, 2000
The Secure Transportable Autonomous Reactor (STAR) concept under development at Argonne National Laboratory provides a small (300 MWt) reactor module for steam supply that incorporates design features to attain proliferation resistance, heightened ...
Sienicki, J. J., Spencer, B. W.
core  

Embedding a Dinuclear Ru─Pt Photocatalyst Into Polyampholytic Graft Copolymer Matrix Enables Prolonged Hydrogen Evolution While Allowing Catalyst Repair

Chemistry – A European Journal, EarlyView.
A unimolecular polyampholytic graft copolymer matrix provides a protective confinement for an electrostatically embedded tetrapyridophenazine‐bridged heterodinuclear Ru‐Pt hydrogen evolving photocatalyst. The matrix slows the degradation kinetics of the catalyst and at the same time does not hinder its repair by ammonium persulfate.
Yurii Utievskyi, Alexander K. Mengele, Mariet Puthanagady, Nikita Vashistha, Linda Zedler, Christof Neumann, Marius Müßler, Andrey Turchanin, Benjamin Dietzek‐Ivanšić, Sven Rau, Felix H. Schacher   +10 more
wiley   +1 more source

Failure simulation of nuclear pressure vessel under LBLOCA scenarios

Nuclear Engineering and Technology
This paper presents the finite element deformation and failure simulation of a typical Korean high-power reactor vessel under a severe accident characterized by large break loss of coolant (LBLOCA) with in-vessel retention of molten corium through ...
Eui-Kyun Park, Jun-Won Park, Yun-Jae Kim, Kukhee Lim, Eung-Soo Kim   +4 more
doaj   +1 more source