Results 71 to 80 of about 137,198 (259)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Jurnal Rekayasa Elektrika, 2018 A solar module as a collector of sunlight that will be converted into electrical energy, so far only used for various applications of renewable energy technology.
Budiyawan Naztin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A comprehensive methodology for the design of solar tower external receivers
Renewable and Sustainable Energy ReviewsThe design optimization of external cylindrical receivers for solar tower plants is a complex task that involves several interrelated factors such as optical performance, thermal losses, pressure drops, mechanical integrity, and capital and operating costs.
Giancarlo Gentile +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Estimating external causes of death in Thailand 1996-2009 based on the 2005 Verbal Autopsy study [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2014 This study aimed to develop models based on Verbal Autopsy (VA) data and to estimate correct number of deaths from external causes in Thailand from 1996 to 2009.
Nuntaporn Klinjun +2 more
doaj
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Mayo Clinic Proceedings: Digital HealthObjective: To create an opportunistic screening model to predict coronary calcium burden and associated cardiovascular risk using only commonly available frontal chest x-rays (CXR) and patient demographics.
Jiwoong Jeong, MS +16 more
doaj +1 more source
Power-Efficient Kerr Frequency Comb Based Tunable Optical Source
IEEE Photonics Journal, 2017 We designed and demonstrated a power-efficient highly integrated photonic system, requiring a total power consumption of 1.7 W and producing a spectrally pure coherent optical signal with a wavelength range of 23 nm in the C-band.
S. Arafin +11 more
doaj +1 more source