Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Experimental and computational studies on the effectiveness of strengthening the concrete floor slabs of a hydroelectric power plant's powerhouse through the use of an external reinforcement system involving carbon tape application. Part I [PDF]
Нанотехнологии в строительствеIntroduction. In accordance with the Federal Law of the Russian Federation ”On the Safety of Hydraulic Structures“, it is necessary to ensure the long-term safety and reliability of operating structures at hydroelectric power plants (HPPs).
Oleg D. Rubin +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Weak and Strong Reinforcement Number For a Graph [PDF]
, 2010 Introducing the weak reinforcement number which is the minimum number of added edges to reduce the weak dominating number, and giving some boundary of this new parameter and ...
DOGAN, Derya +2 more
core +1 more source
Experimental and computational studies on the effectiveness of strengthening the concrete f loor slabs of a hydroelectric power plant's powerhouse through the use of an external reinforcement system involving carbon tape application. Part II [PDF]
Нанотехнологии в строительствеIntroduction. In accordance with the Federal Law of the Russian Federation “On the Safety of Hydraulic Structures”, it is necessary to ensure the long-term safety and reliability of operating structures at hydroelectric power plants (HPP). In a run-of-
Oleg D. Rubin +4 more
doaj +1 more source
The FRP and TRC strengthening of the masonry structures [PDF]
E3S Web of Conferences, 2019 The use of external reinforcement based on carbon fibers is technically and economically justified to strengthen concrete structures, which is confirmed by years of experience.
Granovsky Arkady +2 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The effects of delay to reinforcement and inter-trial interval on fixed-ratio schedule performance [PDF]
, 2013 A delay to reinforcement has been found in previous studies to influence the effectiveness of a reinforcer. As the delay duration increases, response rates decrease and post reinforcement pause durations increase.
Stuart, Stacey Louisa
core
Internal and External Prestress Reinforcement Technology for Prestressed Continuous Box Girder
Zhongwai GongluA prestressed concrete cast-in-situ continuous box girder bridge faces transverse cracking of the bottom plate of the second span and the overall stiffness decline. To address this issue, this paper analyzed the causes of the damage.
SONG Chongyang +3 more
doaj +1 more source