Results 31 to 40 of about 5,407,833 (282)

EXPERIMENTAL INVESTIGATIONS OF REINFORCED CONCRETE STRUCTURES OF HYDRAULIC STRUCTURES WITH BLOCK SEAMS, ENHANCED BY THE EXTERNAL REINFORCEMENT SYSTEM

Structural Mechanics of Engineering Constructions and Buildings, 2018
A method of strengthening reinforced concrete structures by external reinforcement systems based on carbon fiber is widely used. Significant experience is accumulated in industrial and civil construction; there is also a certain experience of strengthening reinforced concrete structures of hydraulic structures.
O D Rubin, S E Lisichkin, K E Frolov
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Direct Tensile Test Method for Shotcrete

Buildings
This study substantiates the need for direct tensile strength testing of shotcrete and fiber-reinforced shotcrete, rather than relying on indirect methods, to accurately reflect material performance under biaxial stress conditions when used for ...
Oleg V. Kabancev, Oleg A. Simakov
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Reinforcement of wood with natural fibers [PDF]

, 2013
This paper describes an experimental programme which examines the reinforcement in flexure of timber beams with composite materials based on natural fibers in the form of fabrics made from hemp, flax, basalt and bamboo fibers.
Borri, Antonio, Speranzini, Emanuela, Corradi, Marco   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Strengthening Of R.C. Beams by External Steel Plate Using Bonded and Unbonded Connectors [PDF]

Engineering and Technology Journal, 2015
Structural rehabilitation represents an important aspect of the construction industry and its significance is increasing. Strengthening is the process of increasing of the existing capacity of a non-damaged structure or a structural component to a ...
Ashraf A. Alfeehan, Rana H. Alkerwei
doaj   +1 more source

POLYMER COMPOSITES FOR EXTERNAL REINFORCEMENT OF BUILDING STRUCTURES

International Journal for Computational Civil and Structural Engineering
Key aspects of developing effective systems for the external reinforcement of building structures, made of composite polymer materials containing carbon fibers and no-bake polymer binders, ensuring shape formation in the temperature range of 15 - 40 °С no more than 24 hours, characterized by operability in the temperature range from minus 45 ° C to ...
Evgeniy Shmoilov, Mikhail Fedotov, Igor Sharutin, Roman Ilyukhin, Stanislav Stepanov, Natalia Panina, Lidiya Gurenchuk, Pavel Kapyrin, Oleg Kabantsev, Oleg Kornev   +9 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source