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What do we really know about the external urethral sphincter?

Continence
The external urethral sphincter (EUS), composed of skeletal muscle, along with a smooth muscle-lined internal urethral sphincter (IUS), have crucial roles in maintaining continence during bladder filling and facilitating urine flow during voiding ...
Karen D. McCloskey, Anthony Kanai, Jalesh N. Panicker, Hikaru Hashitani, Christopher H. Fry   +4 more
doaj   +5 more sources

Concomitant Detrusor and External Urethral Sphincter Botulinum Toxin-A Injections in Male Spinal Cord Injury Patients with Detrusor Overactivity and Detrusor Sphincter Dyssynergia [PDF]

Journal of Rehabilitation Medicine, 2022
Objective: To investigate the effects of concomitant injections of botulinum toxin-A (BoNT-A) into the detrusor and external urethral sphincter muscles in suprasacral spinal cord injured patients with detrusor overactivity and detrusor sphincter ...
Yu-Hui Huang, Sung-Lang Chen
doaj   +2 more sources

Site-Specific Neuromodulation of Detrusor and External Urethral Sphincter by Epidural Spinal Cord Stimulation [PDF]

Frontiers in Systems Neuroscience, 2020
Impairments of the lower urinary tract function including urine storage and voiding are widely spread among patients with spinal cord injuries. The management of such patients includes bladder catheterization, surgical and pharmacological approaches ...
Yuriy Sysoev, Yuriy Sysoev, Elena Bazhenova, Elena Bazhenova, Vsevolod Lyakhovetskii, Vsevolod Lyakhovetskii, Gleb Kovalev, Polina Shkorbatova, Regina Islamova, Natalia Pavlova, Natalia Pavlova, Oleg Gorskii, Oleg Gorskii, Oleg Gorskii, Natalia Merkulyeva, Natalia Merkulyeva, Natalia Merkulyeva, Dmitry Shkarupa, Pavel Musienko, Pavel Musienko, Pavel Musienko, Pavel Musienko   +21 more
doaj   +2 more sources

Changes in urethral smooth muscle and external urethral sphincter function with age in rats [PDF]

Physiological Reports, 2021
To confirm changes in urethral activity with age, both intravesical pressure and urethral perfusion pressure (UPP) were recorded and external urethral sphincter electromyography (EUS‐EMG) was performed.
Takuma Oshiro, Ryu Kimura, Keiichiro Izumi, Asuka Ashikari, Seiichi Saito, Minoru Miyazato   +5 more
doaj   +2 more sources

Urethral preservation by direct anastomosis to bilateral gracilis myocutaneous flaps after distal urethrectomy for extramammary Paget disease: A case report [PDF]

Urology Case Reports
A 47-year-old woman with a 6-year history of vulvar pruritus was diagnosed with vulvar extramammary Paget's disease extending to the urethra, vaginal introitus, and anal canal.
Toshiki Matsushima, Kensuke Mitsunari, Yuichiro Nakamura, Masami Ashizuka, Yutaka Kuwazuka, Ryoichi Imamura   +5 more
doaj   +2 more sources

Metabolic dynamics of human external urethral sphincter myoblast differentiation and the effects of tricarboxylic acid cycle inhibition [PDF]

Scientific Reports
Stress urinary incontinence commonly arises with aging or following prostatectomy, yet its underlying mechanisms remain unclear. To address this, we investigated the role of metabolic pathways—particularly the tricarboxylic acid (TCA) cycle—in the ...
Hironori Kai, Shinro Hata, Noriko Hamamatsu, Mayuka Shinohara, Keiko Matsuura, Hiromitsu Mimata, Toshitaka Shin   +6 more
doaj   +2 more sources

Near-Obliterative Bulbar Urethral Stricture 12 Years After Artificial Urinary Sphincter Implantation: A Case Report. [PDF]

IJU Case Rep
ABSTRACT Introduction Artificial urinary sphincter implantation is guideline‐supported for post‐prostatectomy stress urinary incontinence; however, ultra‐late urethral deterioration remains poorly characterized. Case Presentation A 66‐year‐old man underwent radical retropubic prostatectomy in December 2006, followed by salvage radiotherapy in April ...
Niimura T, Horiguchi A, Niimura S.
europepmc   +2 more sources

Physiological medium and 3-hydroxybutyrate modulate autophagy-linked organelle remodeling in human external urethral sphincter myoblasts [PDF]

Scientific Reports
Autophagy-linked organelle remodeling is essential for skeletal muscle differentiation and is closely linked to the metabolic environment. The ketone body 3-hydroxybutyrate (3HB) serves as an alternative energy substrate and signaling molecule that ...
Hironori Kai, Shinro Hata, Noriko Hamamatsu, Ryoko Shiraishi, Toshitaka Shin   +4 more
doaj   +2 more sources

Brainstem neurons coordinate the bladder and urethral sphincter for urination [PDF]

eLife
Urination, a vital and conserved process of emptying urine from the urinary bladder in mammals, requires precise coordination between the bladder and external urethral sphincter (EUS) that is tightly controlled by a complex neural network.
Xing Li, Xianping Li, Jun Li, Han Qin, Shanshan Liang, Jun Li, Tingliang Jian, Xia Wang, Lingxuan Yin, Chunhui Yuan, Xiang Liao, Hongbo Jia, Xiaowei Chen, Jiwei Yao   +13 more
doaj   +2 more sources

Sphincter preservation techniques during radical prostatectomies: Lessons learned

Urology Annals, 2023
Prolonged urinary incontinence represents one of the most severe complications after a radical prostatectomy procedure, significantly affecting patients' quality of life.
Theodoros Spinos, Iason Kyriazis, Arman Tsaturyan, Jens-Uwe Stolzenburg, Evangelos Liatsikos, Abdulrahman Al-Aown, Panagiotis Kallidonis   +6 more
doaj   +1 more source