Results 31 to 40 of about 56,405 (311)
Buchanan and Pro-Social Behaviors: Why Ethics is Necessary
Œconomia, 2015 In this paper, we analyze the role of ethics and self-interest in Buchanan's explanation for pro-social behaviors. Our main argument is that, to Buchanan, ethics matters and is even necessary to explain pro-social behaviors—narrowly self-interested ...
Alain Marciano
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Optimization of territorial ecological space under the constraint of ecosystem service externalities
Ecological IndicatorsEcosystem services are dynamic, following specific paths between regions and generating externalities. However, research on these externalities and the mechanisms within ecological networks remains limited.
Junxiao Wang +5 more
doaj +1 more source
Ostrom, Floods and Mismatched Property Rights
International Journal of the Commons, 2020 How societies can cope with flood risk along coasts and riverbanks is a critical theoretical and empirical problem – particularly in the wake of anthropogenic climate change and the increased severity of floods.
Nick Cowen, Charles Delmotte
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The Externality of Discounted Externalities
Journal of Law and Political EconomyThis article addresses an unexplored problem in the externalities literature: the present value of future externalities. The problem arises because externalized costs and benefits occur in the future, and therefore should be discounted, yet discount rates used by corporate decision-makers are typically higher than the appropriate social discount rate ...
Greenfield, Kent, Partnoy, Frank
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
On the Relevance of Wrongfulness to the Concept of Externalities
Œconomia, 2015 This paper examines the concept of externalities using the concepts of rights and corrective justice as an alternative to utilitarianism and efficiency.
Mark D. White
doaj +1 more source
Review of World Economics, 2004 Gross stocks of foreign assets have increased rapidly relative to national outputs since 1990, and the short-run capital gains and losses on those assets can amount to significant fractions of GDP. These fluctuations in asset values render the national income and product account measure of the current account balance increasingly inadequate as a ...
openaire +3 more sources