Results 31 to 40 of about 2,625,869 (258)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Global analysis of a new nonlinear stochastic differential competition system with impulsive effect
Advances in Difference Equations, 2017 We propose a new stochastic competition chemostat system with saturated growth rate and impulsive toxicant input. The main purpose of this paper is to study the stochastic dynamics of a high-dimensional impulsive stochastic chemostat model and find the ...
Xuejin Lv, Lu Wang, Xinzhu Meng
doaj +1 more source
Scaling laws in the evolutionary processes of marine animals over the last 540 million years
Geosystems and GeoenvironmentScaling laws are ubiquitous in modern biological systems. However, whether such patterns existed in deep-time biological systems is less investigated; the best-known example is the scaling law between the frequency and size of extinction events.
Haitao Shang
doaj +1 more source
Protein‐Nanoarchitectures for Low‐Field Intracellular Electro‐Immunomodulation
Advanced Functional Materials, EarlyView.DHQ‐SDH‐mediated binding of AuNPs drives the formation of interconnected, chain‐like nanoarchitectures with enhanced electrical conductivity. These conductive assemblies undergo macrophage uptake and enable low‐field electrical stimulation, promoting M1‐to‐M2 phenotypic switching with decreased iNOS and increased CD206 expression. Such protein‐mediated
Viktoriya Pakharenko +7 more
wiley +1 more source
Routledge Open ResearchIn recent years, extinction has become something of a buzzword used to portray the state of consciousness of the epoch. Its definition as a concept, however, heavily oscillates between naturalistic, speculative, ethical and critical connotations. The aim
Gregorio Tenti
doaj +1 more source
Advanced Functional Materials, EarlyView.Nitride MXenes remain constrained by a persistent gap between computational prediction and experimental realization. This Review identifies the thermodynamic, kinetic, and chemical barriers limiting their synthesis, critically evaluates emerging fabrication routes, and proposes a multidimensional computational‐experimental framework to accelerate the ...
Naresh Varnakavi, Masoud Soroush
wiley +1 more source
Heavy metal toxicity and its role as a major driver of past biodiversity crises
Communications Earth & EnvironmentWhether today’s heavy metal pollution constitutes an unprecedented threat to biodiversity remains unresolved. Although evidence of metal enrichment exists for several deep-time biotic crises, direct causal links to extinction are lacking.
Francesca Galasso +2 more
doaj +1 more source