Results 21 to 30 of about 217,735 (267)

Cannabidiol regulation of learned fear: implications for treating anxiety-related disorders

Frontiers in Pharmacology, 2016
Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress disorder (PTSD) are characterized by abnormal and persistent memories of fear-related contexts and cues.
Regimantas Jurkus, Harriet Laura Lavinia Day, Francisco S. Guimaraes, Jonathan L C Lee, Leandro Jose Bertoglio, Carl W. Stevenson   +5 more
doaj   +1 more source

Has the Polyploid Wave Ebbed?

Frontiers in Plant Science, 2020
There was a wave of whole genome duplications (WGD) during and subsequent to the K-Pg interface, which was followed by an increase in the proportion of species that were polyploid.
Donald A. Levin
doaj   +1 more source

Identification of the Similarities and Differences of Molecular Networks Associated With Fear Memory Formation, Extinction, and Updating in the Amygdala

Frontiers in Molecular Neuroscience, 2021
Abnormality of fear memory is one of the important pathogenic factors leading to post-traumatic stress disorder (PTSD), anxiety disorder, and other mental disorders.
Jinfeng Su, Jinfeng Su, Pingping Li, Qishuai Zhuang, Xing Chen, Xiaoning Zhang, Xiaobing Li, Jingxian Wang, Xiaohan Yu, Yue Wang, Yue Wang   +10 more
doaj   +1 more source

From Bench to Brain: A Metadata-driven Approach to Research Data Management in a Collaborative Neuroscientific Research Center

Data Science Journal
Research data management (RDM) is key to fast and effective cooperation in collaborative research projects, especially when several scientific disciplines are involved.
Marlene Pacharra, Tobias Otto, Nina Olivia Caroline Winter   +2 more
doaj   +1 more source

Urban forest fragments as unexpected sanctuaries for the rare endemic ghost butterfly from the Atlantic forest

Ecology and Evolution, 2019
Anthropogenic land expansion, particularly urbanization, is pervasive, dramatically modifies the environment and is a major threat to wildlife with its associated environmental stressors. Urban remnant vegetation can help mitigate these impacts and could
Antonio C. deAndrade, William Medeiros, Matthew Adams   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

De-Extinction [PDF]

Genes, 2018
De-extinction projects for species such as the woolly mammoth and passenger pigeon have greatly stimulated public and scientific interest, producing a large body of literature and much debate. To date, there has been little consistency in descriptions of de-extinction technologies and purposes.
openaire   +2 more sources

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Rethinking Extinction [PDF]

Neuron, 2015
Extinction serves as the leading theoretical framework and experimental model to describe how learned behaviors diminish through absence of anticipated reinforcement. In the past decade, extinction has moved beyond the realm of associative learning theory and behavioral experimentation in animals and has become a topic of considerable interest in the ...
Dunsmoor, Joseph E., Niv, Yael, Daw, Nathaniel, Phelps, Elizabeth A.   +3 more
openaire   +2 more sources