Results 121 to 130 of about 215,567 (277)

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

open access: yesAdvanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka   +10 more
wiley   +1 more source

Pengarna eller livet – En kvalitativ gestaltningsanalys av Extinction Rebellion Sveriges pressmeddelanden

open access: yes, 2020
Syftet med denna studie är att undersöka hur den klimataktivistiska organisationen Extinction Rebellion Sverige gestaltar klimatfrågan och på vilka sätt denna gestaltning ligger till grund för skapandet av en kollektiv identitet.
Lindholm, Kalle
core   +1 more source

‘That is the bet’: theories of change in the strategies of the Italian climate movement

open access: yesPolitical Research Exchange
Research on differences within the climate movement has been focusing for a long time on the emergence of the ‘climate justice’ frame within this trajectory as a way out of a post-political understanding of climate action, as well as on tensions on the ...
Lorenzo Zamponi, Marco Deseriis
doaj   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

open access: yesAdvanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee   +5 more
wiley   +1 more source

Reversible, Chemically Gated FRET via Ligand‐Activated Acceptors

open access: yesAdvanced Science, EarlyView.
Fluorogen binding turns the compact FAST tag into a tunable FRET acceptor, with ligand chemistry programming spectral overlap and excited‐state lifetimes. Fluorescence‐lifetime imaging reads out energy transfer through the shortened donor lifetime, while simply adding or washing out the dye switches FRET on and off, reversibly mapping the supramodular ...
Nivedita Singh   +7 more
wiley   +1 more source

“Even the Small Work That I Do, It Has Impact, It Has Meaning”: Collective Meaning-Making in Youth Climate Groups

open access: yesSocial Sciences
This article focuses on participation in youth-led climate-oriented groups and the role of this form of civic engagement for young people. Thirty interviews were conducted with 13- to 18-year-olds belonging to four groups: Extinction Rebellion Youth ...
Julia L. Ginsburg   +1 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

open access: yesAdvanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang   +12 more
wiley   +1 more source

Cross‐scale Material‐Structure Synergy for 2D Metamaterials: Toward Customizable Intelligent Electromagnetic Manipulation in Multiphysics Fields

open access: yesAdvanced Science, EarlyView.
Recent advances in metasurface‐enabled low‐observable technologies are reviewed from the perspective of cross‐scale material–structure synergy. Electromagnetic, thermal, optical, and acoustic stealth are highlighted together with dynamic tuning, programmable coding, data‐driven inverse design, artificial intelligence, multispectral compatibility, and ...
Shuhao Wang   +5 more
wiley   +1 more source

Understanding Environmental NGOs’ Inclusiveness: A Comparative Analysis of Two Australian Climate Action Groups

open access: yesNonprofit Policy Forum
It is a perennial challenge for different political organisations, including environmental NGOs (ENGOs), to accommodate diverse social and political groups’ interests, opinions, and experiences.
Chang Patrick
doaj   +1 more source

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