Results 41 to 50 of about 920,837 (294)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Extra-Articular Manifestations of Rheumatoid Arthritis & its relation with Treatment Outcome: a tertiary care hospital experience

, 2017
Objective: This study was done to determine frequency of extra-articular manifestations (ExRA) in patients with rheumatoid arthritis (RA) and its relation with treatment outcome in a tertiary care hospital, Dhaka.Methods: A cross sectional study was ...
Nazmul Kabir Qureshi, Md Azizul Hoque, Md Mujibur Rahman, Nazma Akter   +3 more
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Rheumatoid nodules in thyroid gland parenchyma as an expression of rheumatoid arthritis: a case report

Journal of Medical Case Reports, 2019
Background The rheumatoid nodule is the most common extra-articular manifestation of rheumatoid arthritis. When present, it is readily identified in conventional hematoxylin and eosin sections.
Efthimios Sivridis, Maria Kouroupi, Michael Ioannis Koukourakis, Stella Arelaki, Nikolaos Lyratzopoulos, Alexandra Giatromanolaki   +5 more
doaj   +1 more source

A Study on the Extra-Articular Manifestations of Rheumatoid Arthritis [PDF]

, 2019
BACKGROUND AND OBJECTIVES: Rheumatoid arthritis is a common systemic inflammatory disease. Extra- articular manifestations are a common occurrence and are part of the spectrum of the disease.
Ponmozhi, G
core  

Cross-reactive rheumatoid factors inrheumatoid arthritis with extra-articular disease

, 1990
SUMMARY Rheumatoid factors (RF) have been shown to have considerable heterogeneity and bind with IgG aswell as with a variety of substances such as nuclear histone, non-histone nuclear protein, nitrophenylgroups or ssDNA.
S AOTSUKA, R YOKOHARI, M KINOSHITA
core   +1 more source

Case series : dual-energy CT in extra-articular manifestations of gout [PDF]

, 2020
Extra-articular manifestations of gout are common. The Achilles tendon is a frequently affected site, and uric acid deposition may have harmful effects on tendon structure and function.
Verstraete, Koenraad, Jans, Lennart, Huysse, Wouter, Chen, Min, De Vulder, Nando, Herregods, Nele   +5 more
core   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

SPECTRUM OF RHEUMATOID ARTHRITIS PATIENTS PRESENTING TO A TERTIARY CARE HOSPITAL IN PAKISTAN

Pakistan Armed Forces Medical Journal, 2021
Objective: To describe the demographic, clinical, serological and radiological scores in patients with rheumatoid arthritis (RA) presenting in a tertiary hospital in Pakistan. Study Design: Cross sectional study.
Muhammad khan, Muhammad Salman Mushtaq, Babur Salim, Sumera Mushtaq, Haris Gul, Saba Samreen   +5 more
doaj   +1 more source