Results 1 to 10 of about 43,879 (232)

Understanding the Pathogenesis of Spondyloarthritis [PDF]

Biomolecules, 2020
Spondyloarthritis comprises a group of inflammatory diseases of the joints and spine, with various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis associated with inflammatory bowel ...
Jeannette Kunz, Aigul Sharip
exaly   +4 more sources

Case Report: Achilles enthesitis as the presenting clue to occult sacroiliitis in hidradenitis suppurativa [PDF]

Frontiers in Medicine
Hidradenitis suppurativa is increasingly recognized as a systemic inflammatory disease with an established overlap with spondyloarthritis. Axial spondyloarthritis is usually suspected when patients report inflammatory back pain, which remains the entry ...
Mohamed Bedaiwi
doaj   +2 more sources

Spondyloarthritis Research and Treatment Network Recommendations for the Referral of Adults With Chronic Back Pain and Suspected Axial Spondyloarthritis to a Rheumatologist. [PDF]

ACR Open Rheumatol
Objective In the United States, axial spondyloarthritis (axSpA) diagnosis is delayed up to 14 years preventing effective management. We convened a multidisciplinary clinician and patient group to develop recommendations for rheumatology referral of adults with chronic back pain.
Dubreuil M, Danve A, Liew JW, Alexander SA, Afinogenova Y, Bittar M, Fraenkel L, Grimshaw A, Kumthekar A, LaValley MP, Magrey MN, Majithia V, Merjanah S, Norton H, Walsh JA, Deodhar A.   +15 more
europepmc   +2 more sources

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis. [PDF]

Arthritis Care Res (Hoboken)
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Weiss PF, Smith JA, Colbert RA, Treemarcki E, Weisman MH, Maksymowych WP, Brunner HI, Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council.   +9 more
europepmc   +2 more sources

Correction to "HLA-B Associates With Distinct Disease Expression in Juvenile Spondyloarthritis: A Retrospective Cohort Study". [PDF]

ACR Open Rheumatol
ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
europepmc   +2 more sources

Clinical Phenotypes, Treatment, and Outcomes of Rheumatic Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitors: A Rheumatologists-Referred Multicenter German Registry Cohort. [PDF]

ACR Open Rheumatol
Objective Immune checkpoint inhibitors (ICIs) induce a broad range of immune‐related adverse events (irAEs), including rheumatic manifestations. Evidence from dedicated rheumatology cohorts on the clinical spectrum, severity, treatment, and outcomes of rheumatic irAEs (rh‐irAEs) remains limited.
Gailis D, Ullrich FTH, Dombret S, Schmalzing M, Hasseli-Fräbel R, Witte T, Thiele T, Kiltz U, Oleszowsky M, Müller M, Gente K, Specker C, Thaler MB, Skapenko A, Schulze-Koops H.   +14 more
europepmc   +2 more sources

Reduction of CXCR3+CCR6+ CD4+ T Cells and IL-17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy. [PDF]

ACR Open Rheumatol
Objective We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that could determine their next biologic ...
Pacheco A, Remalante-Rayco P, Haroon N, Poddubnyy D, Inman RD.   +4 more
europepmc   +2 more sources

Extra-musculoskeletal manifestations driving the therapeutic decision-making in patients with Spondyloarthritis: a 12-month follow-up prospective cohort study

Advances in Rheumatology, 2023
Background The extra-musculoskeletal manifestations (EMMs) such as recurrent acute anterior uveitis (rAAU), psoriasis (Ps), and inflammatory bowel disease (IBD), are related to the Spondyloarthritis (SpA), as well as they are associated with disease ...
Danielle dos Reis Annunciato, Thauana Luiza Oliveira, Vanessa Oliveira Magalhães, Marcelo de Medeiros Pinheiro   +3 more
doaj   +1 more source

Association of Genetic Marker HLA-B27 with Spondyloarthritis In A Tertiary Care Centre In South India

Journal of Pure and Applied Microbiology, 2022
Human leukocyte antigens (HLA) are gene products found in the major histocompatibility complex, aiding in differentiation of “self” from “non-self” antigens, and is crucial for the communication between immune cells of the human body.
T. Jayaprakash, Om Lokesh Muthamilan, K.V. Leela, C. Panchapakesa Rajendran, Arul Raja Murugan, Sujith Ravi   +5 more
doaj   +1 more source

Differentiating nonradiographic axial spondyloarthritis from its mimics: a narrative review

BMC Musculoskeletal Disorders, 2022
Background Optimal treatment of nonradiographic axial spondyloarthritis depends on accurate and timely diagnosis of the underlying disease; however, patients present with common symptoms that, in the absence of radiographic changes, may confound ...
Philip Mease, Atul Deodhar
doaj   +1 more source