Results 81 to 90 of about 113,827 (266)

Physics with large extra dimensions [PDF]

open access: yesNuclear Physics B - Proceedings Supplements, 2003
The recent understanding of string theory opens the possibility that the string scale can be as low as a few TeV. The apparent weakness of gravitational interactions can then be accounted by the existence of large internal dimensions, in the sub-millimeter region.
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Primordial Black Holes from Spatially Varying Cosmological Constant Induced by Field Fluctuations in Extra Dimensions

open access: yesUniverse
The origin and evolution of supermassive black holes (SMBHs) in our universe have sparked controversy. In this study, we explore the hypothesis that some of these black holes may have seeded from the direct collapse of dark energy domains with density ...
Arkady A. Popov   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

GIMPs from extra dimensions

open access: yesPhysics Letters B, 2010
We study a scalar field theory in a flat five-dimensional setup, where a scalar field lives in a bulk with a Dirichlet boundary condition, and give an implementation of this setup to the Froggatt- Nielsen (FN) mechanism. It is shown that all couplings of physical field of the scalar with the all brane localized standard model particles are vanishing ...
Holthausen, M., Takahashi, R.
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Searches for power-law warped extra dimensions

open access: yesJournal of High Energy Physics
Extra dimensions with a bulk dilaton field can be power-law warped, unlike the exponential warping in the Randall-Sundrum (RS) model. We show that this mildly warped extra dimension can address the hierarchy problem with a novel Kaluza-Klein (KK ...
Sang Hui Im, Krzysztof Jodłowski
doaj   +1 more source

4 + n-dimensional water and waves on four and eleven-dimensional manifolds

open access: yesOpen Physics, 2018
In this paper, we consider the structure of water and waves from viewpoints of two observers, one on 4-dimensional manifold and the other on 11-dimensional manifold.
Sepehri Alireza, Fioranelli Massimo
doaj   +1 more source

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