Results 91 to 100 of about 1,944,890 (372)

ATP is an essential autocrine factor for pancreatic β‐cell signaling and insulin secretion

Physiological Reports, 2022
ATP has been previously identified as an autocrine signaling factor that is co‐released with insulin to modulate and propagate β‐cell activity within islets of Langerhans.
Sebastian Hauke, Jona Rada, Gergely Tihanyi, Danny Schilling, Carsten Schultz   +4 more
doaj   +1 more source

New Technologies for Analysis of Extracellular Vesicles.

Chemical Reviews, 2018
Extracellular vesicles (EVs) are diverse, nanoscale membrane vesicles actively released by cells. Similar-sized vesicles can be further classified (e.g., exosomes, microvesicles) based on their biogenesis, size, and biophysical properties.
Huilin Shao, H. Im, Cesar M. Castro, X. Breakefield, R. Weissleder, Hakho Lee   +5 more
semanticscholar   +1 more source

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

Journal of Extracellular Vesicles, 2021
In this study we tested whether a protein corona is formed around extracellular vesicles (EVs) in blood plasma. We isolated medium‐sized nascent EVs of THP1 cells as well as of Optiprep‐purified platelets, and incubated them in EV‐depleted blood plasma ...
Eszter Á. Tóth, Lilla Turiák, T. Visnovitz, C. Cserép, A. Mázló, Barbara W. Sódar, András I Försönits, G. Petővári, A. Sebestyén, Z. Komlósi, L. Drahos, Á. Kittel, G. Nagy, A. Bácsi, Á. Dénes, Y. Gho, K. Szabó-Taylor, E. Buzás   +17 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

A modular method for the extraction of DNA and RNA, and the separation of DNA pools from diverse environmental sample types

Frontiers in Microbiology, 2015
A method for the extraction of nucleic acids from a wide range of environmental samples was developed. This method consists of several modules, which can be individually modified to maximize yields in extractions of DNA and RNA or separations of DNA ...
Mark Alexander Lever, Mark Alexander Lever, Andrea eTorti, Philip eEickenbusch, Alexander Bryce Michaud, Tina eŠantl-Temkiv, Bo Barker Jørgensen   +6 more
doaj   +1 more source

Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)

Journal of Cardiovascular Magnetic Resonance, 2017
Parametric mapping techniques provide a non-invasive tool for quantifying tissue alterations in myocardial disease in those eligible for cardiovascular magnetic resonance (CMR).
D. Messroghli, J. Moon, V. Ferreira, L. Grosse-Wortmann, T. He, P. Kellman, J. Mascherbauer, R. Nezafat, M. Salerno, E. Schelbert, A. Taylor, Richard B. Thompson, M. Ugander, Ruud B. van Heeswijk, M. Friedrich   +14 more
semanticscholar   +1 more source

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Nature Cell Biology, 2021
Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular nanoparticle, termed supermere.
Qin Zhang, Dennis K. Jeppesen, J. Higginbotham, Ramona Graves‐Deal, V. Q. Trinh, M. Ramirez, Yoojin Sohn, Abigail C. Neininger, Nilay Taneja, Eliot T. McKinley, Hiroaki Niitsu, Z. Cao, R. Evans, Sarah E. Glass, Kevin C. Ray, W. Fissell, S. Hill, Kristie L. Rose, W. J. Huh, M. Washington, G. Ayers, D. Burnette, Shivani Sharma, L. Rome, J. Franklin, Youngmin A. Lee, Qi Liu, R. Coffey   +27 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

eDNA State and Medium Affect DNA Degradation Patterns in Seminatural Systems of Southern African Waterholes

Environmental DNA
Environmental DNA (eDNA) has evolved into a valuable asset of the ecologists' toolkit, enabling time‐ and cost‐efficient biodiversity assessments in a wide variety of ecosystems.
Irmgard Sedlmayr, Tamara Schenekar
doaj   +1 more source

Active C4 Electrodes for Local Field Potential Recording Applications

Sensors, 2016
Extracellular neural recording, with multi-electrode arrays (MEAs), is a powerful method used to study neural function at the network level. However, in a high density array, it can be costly and time consuming to integrate the active circuit with the ...
Lu Wang, David Freedman, Mesut Sahin, M. Selim Ünlü, Ronald Knepper   +4 more
doaj   +1 more source