Results 81 to 90 of about 2,129,035 (302)

The International Society for Extracellular Vesicles launches the first massive open online course on extracellular vesicles [PDF]

, 2016
The International Society for Extracellular Vesicles (ISEV) has organised its first educational online course for students and beginners in the field of extracellular vesicles (EVs). This course, “Basics of Extracellular Vesicles,” uses recorded lectures
Lötvall, Jan,, Lötvall, Jan, Mathivanan, Suresh, Lässer, Cecilia, Théry, Clotilde, Buzás, E.I., Mathivanan, S., Lötval, J., Buzás, Edit I, Yong Song Gho, Lässer, C., Zhao, Weian, Gho, Yong Song, Zhao, W., Gho, Yong Song,, Edit I. Buzás, Jan Lötvall, Lässer, Cecilia,, Gho, Y.S., Suresh Mathivanan, Weian Zhao, Théry, C., Cecilia Lässer, Clotilde Théry   +23 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Optimized protocol for quantification of extracellular nicotinamide adenine dinucleotide: evaluating clinical parameters and pre-analytical factors for translational research

Frontiers in Medicine
Nicotinamide adenine dinucleotide (NAD+), a coenzyme for more than 500 enzymes, plays a central role in energy production, metabolism, cellular signaling, and DNA repair. Until recently, NAD+ was primarily considered to be an intracellular molecule (iNAD+
Al-Hussein Ahmed Saqr, Can Kamali, Philipp Brunnbauer, Nils Haep, Pia Koch, Karl-Herbert Hillebrandt, Karl-Herbert Hillebrandt, Eriselda Keshi, Eriselda Keshi, Simon Moosburner, Simon Moosburner, Raphael Mohr, Nathanael Raschzok, Johann Pratschke, Felix Krenzien, Felix Krenzien   +15 more
doaj   +1 more source

The influence of extracellular tissue on neutrophil function and its possible linkage to inflammatory diseases

Immunity, Inflammation and Disease, 2021
Background: Migration, production of reactive oxygen species (ROS), release of myeloperoxidase (MPO), and NETosis are functional immunological reactions of elementary importance for polymorphonuclear neutrophils (PMN).
Richard F. Kraus, Michael A. Gruber, Martin Kieninger   +2 more
doaj   +1 more source

Neutrophil extracellular traps [PDF]

Current Biology, 2011
What are neutrophil extracellular traps, or NETs? Neutrophils, the most abundant immune cells in humans, are the first line of defense against invading pathogens. They employ a wide array of anti-microbial strategies, most notably phagocytosis, to attack and eliminate pathogens.
Amulic, Borko, Hayes, Garret
openaire   +4 more sources

Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]

, 2013
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
Maria Scarselli (247406), Norais Nathalie, Jeffrey T. Rubino (490079), Norais, Nathalie, Leuzzi, Rosanna, Massimiliano Biagini, Biagini Massimiliano, Martinelli Manuele, Scarselli, Maria, Jeffrey T Rubino, Serruto Davide, Manuele Martinelli, Rosanna Leuzzi (490078), Nathalie Norais, Davide Serruto, Rosanna Leuzzi, Rubino, Jeffrey T., Nathalie Norais (159651), Serruto, Davide, Unnikrishnan, Meera, Manuele Martinelli (272421), Cantini Francesca, Francesca Cantini, Maria Scarselli, Martinelli, Manuele, Cantini, Francesca, Biagini, Massimiliano, Meera Unnikrishnan, Rubino Jeffrey T., Valeria Cafardi (490077), Massimiliano Biagini (247421), Unnikrishnan Meera, Cafardi, Valeria, Leuzzi Rosanna, Cafardi Valeria, Valeria Cafardi, Meera Unnikrishnan (183268), Scarselli Maria, Francesca Cantini (208272), Davide Serruto (148434)   +39 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

SnapShot: Extracellular Vesicles

Cell, 2020
Cells release a variety of extracellular vesicles (EVs; including exosomes, microvesicles, and many others) into their environment. EVs can bud in endosomes or directly at the plasma membrane, carrying a selection of components from the cell and displaying various functional properties.
Cocozza, Federico, Grisard, Eleonora, Martin-Jaular, Lorena, Mathieu, Mathilde, Théry, Clotilde   +4 more
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Extracellular vesicles are integral and functional components of the extracellular matrix

Matrix Biology, 2019
Extracellular vesicles (EV) are small plasma membrane-derived particles released into the extracellular space by virtually all cell types. Recently, EV have received increased interest because of their capability to carry nucleic acids, proteins, lipids and signaling molecules and to transfer their cargo into the target cells.
Kirsi Rilla, Anne-Mari Mustonen, Uma Thanigai Arasu, Kai Härkönen, Johanna Matilainen, Petteri Nieminen   +5 more
openaire   +3 more sources