Results 61 to 70 of about 2,129,035 (302)

A modular method for the extraction of DNA and RNA, and the separation of DNA pools from diverse environmental sample types

Frontiers in Microbiology, 2015
A method for the extraction of nucleic acids from a wide range of environmental samples was developed. This method consists of several modules, which can be individually modified to maximize yields in extractions of DNA and RNA or separations of DNA ...
Mark Alexander Lever, Mark Alexander Lever, Andrea eTorti, Philip eEickenbusch, Alexander Bryce Michaud, Tina eŠantl-Temkiv, Bo Barker Jørgensen   +6 more
doaj   +1 more source

Modulation of Inflammation by Extracellular Granzyme A

Frontiers in Immunology, 2020
Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells.
Kim R. van Daalen, Josephine F. Reijneveld, Niels Bovenschen, Niels Bovenschen   +3 more
doaj   +1 more source

THE EXTRACELLULAR RELEASE OF ECHINOCHROME [PDF]

Journal of General Physiology, 1946
A study was made of the diffusion of the red pigment echinochrome from the eggs of the sea urchin, Arbacia punctulata, into sea water. Unfertilized eggs retained their pigment, over periods of hours. Outward diffusion of pigment from unfertilized eggs normally is entirely negligible, or does not occur at all.
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Sputum Glutaredoxin 1 and Protein S-Glutathionylation in COPD

Antioxidants
Alterations in glutathione and its metabolism contribute to oxidative stress in COPD, but the role of S-glutathionylation (PSSG) and its major regulator glutaredoxin 1 (Grx1) remains unclear.
Ine Kuipers, Renske Krijgsman, Renaud Louis, Jean-Louis Corhay, Thibault Azevedo Mendes, Guy G. Brusselle, Ken R. Bracke, Niki L. Reynaert   +7 more
doaj   +1 more source

Control of Intracellular Calcium Signaling as a Neuroprotective Strategy

Molecules, 2010
Both acute and chronic degenerative diseases of the nervous system reduce the viability and function of neurons through changes in intracellular calcium signaling.
R. Scott Duncan, Daryl L. Goad, Michael A. Grillo, Simon Kaja, Andrew J. Payne, Peter Koulen   +5 more
doaj   +1 more source

Reduction in Glomerular and Renal Tubular Damage in Kidneys of Diabetic Rats Supplemented with Alpha-Lipoic Acid

Acta Veterinaria, 2022
Chronic hyperglycemia caused by diabetes results in systemic damage to the body, and the kidney ends up being the target of tissue damage. The use of antioxidants such as alpha-lipoic acid (ALA) has been shown to improve clinical and biochemical ...
Fraga Tamyris Pontes, Corrêa Lanna Beatriz Neves Silva, Taboas Julia Galian Ribeiro, Da Silva Vivian Alves Pereira, Boaventura Gilson Teles, Chagas Mauricio Alves   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cooperative antibiotic resistance in bacteria: beyond biofilms

Frontiers in Microbiology
Cooperative behaviors among microorganisms, such as biofilm formation, are widespread and play a key role in the emergence and evolution of antibiotic resistance by promoting genetic exchange and environmental adaptability.
Qinqin Wang, Valentine Cyriaque, Valentine Cyriaque, Valentine Cyriaque, Jonas Stenløkke Madsen   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source