Results 131 to 140 of about 3,262,386 (333)

Molecular insights into the unique properties of the blood‐circulating proteasome

Journal of Extracellular Biology
Proteasomes are essential for protein degradation and maintaining cellular balance, yet their roles in extracellular fluids are not well understood.
Yegor Leushkin, David Morgenstern, Shifra Ben‐Dor, Rebecca Haffner‐Krausz, Katharina Zittlau, Gili Ben‐Nissan, Michal Sharon   +6 more
doaj   +1 more source

Optimized protocol for quantification of extracellular nicotinamide adenine dinucleotide: evaluating clinical parameters and pre-analytical factors for translational research

Frontiers in Medicine
Nicotinamide adenine dinucleotide (NAD+), a coenzyme for more than 500 enzymes, plays a central role in energy production, metabolism, cellular signaling, and DNA repair. Until recently, NAD+ was primarily considered to be an intracellular molecule (iNAD+
Al-Hussein Ahmed Saqr, Can Kamali, Philipp Brunnbauer, Nils Haep, Pia Koch, Karl-Herbert Hillebrandt, Karl-Herbert Hillebrandt, Eriselda Keshi, Eriselda Keshi, Simon Moosburner, Simon Moosburner, Raphael Mohr, Nathanael Raschzok, Johann Pratschke, Felix Krenzien, Felix Krenzien   +15 more
doaj   +1 more source

Intracellular and Extracellular Metabolites from the Cyanobacterium Chlorogloeopsis fritschii, PCC 6912, During 48 Hours of UV-B Exposure

Metabolites, 2019
Cyanobacteria have many defence strategies to overcome harmful ultraviolet (UV) stress including the production of secondary metabolites. Metabolomics can be used to investigate this altered metabolism via targeted and untargeted techniques.
Bethan Kultschar, Ed Dudley, Steve Wilson, Carole A. Llewellyn   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes

ADMET and DMPK, 2019
One of the primary objectives of physiologically based pharmacokinetics (PBPK) is the prediction of a drug’s pharmacokinetics just from knowledge of its physicochemical structure.
David G. Levitt
doaj   +1 more source

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development [PDF]

, 2019
Laurence Macia, Ralph Nanan, Elham Hosseini‐Beheshti, Georges E. Grau   +3 more
openalex   +1 more source

MSC-Derived Extracellular Vesicles Activate Mitophagy to Alleviate Renal Ischemia/Reperfusion Injury via the miR-223-3p/NLRP3 Axis [PDF]

, 2022
Zejia Sun, Zihao Gao, Jiyue Wu, Xiang Zheng, Shizhao Jing, Wei Wang   +5 more
openalex   +1 more source

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

BioMed Research International, 2018
Background Extracellular vesicles (EVs) play an essential role in the communication between cells and transport of diagnostically significant molecules.
M. Konoshenko, E. Lekchnov, A. Vlassov, P. Laktionov   +3 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Size‐exclusion chromatography‐based enrichment of extracellular vesicles from urine samples [PDF]

, 2015
Inés Lozano‐Ramos, Ioana Bancu, Anna Oliveira‐Tercero, María Pilar Armengol, Armando Menezes‐Neto, Hernando A. del Portillo, Ricardo Lauzurica‐Valdemoros, Francesc E. Borràs   +7 more
openalex   +1 more source