Results 121 to 130 of about 2,129,035 (302)

Extracellular Vesicles and Extracellular RNAs in Plant–Microbe Interactions

Annual Review of Plant Biology
Plants and microbes exchange macromolecules such as RNA and proteins. How this exchange is accomplished is poorly understood, but extracellular vesicles (EVs) have been proposed as likely vehicles. Here, we review recent work on the biogenesis and functions of plant EVs and the current evidence in support of and against their role in cross-kingdom RNA ...
Benjamin L, Koch, Meenu, Singla-Rastogi, Roger W, Innes   +2 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Extracellular MicroRNAs: A Stable and Diverse Source of Transcriptional Control

Biomolecules
MicroRNAs (miRNAs) are a highly conserved class of small (19–25 nucleotides) non-coding RNAs that play critical roles in post-translational gene regulation.
Megan I. Mitchell, Olivier Loudig
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Emerging roles of extracellular vesicles in the adaptive response of tumour cells to microenvironmental stress. [Elektronisk resurs]

, 2013
Cells are constantly subjected to various types of endogenous and exogenous stressful stimuli, which can cause serious and even permanent damage. The ability of a cell to sense and adapt to environmental alterations is thus vital to maintain tissue ...
Belting, Mattias,, Kucharzewska, Paulina,, Lund University.   +2 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Beyond basic characterization and omics : Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing

Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases.
Oxvig, Claus,, Kari, Otto K., Kari, Otto, Masood Kamali‐Moghaddam, Federico, Antonio,, Siljander, Pia R.M., Rikke Halse Østergaard, Kamali-Moghaddam, Masood,, Laitinen, Saara, Eble, Johannes A., Kjaer-Sorensen, Kasper, Hayashi, Yuya, Kasper Kjaer‐Sorensen, Joseph Ndika, Palviainen, Mari, Greco, Dario,, Juan M. Falcon‐Perez, Mari Palviainen, Laitinen, Saara,, Saara Laitinen, Palviainen, Mari,, Claus Oxvig, Aransay, Ana M.,, Federico, Antonio, Maaninka, Katariina, Ana M. Aransay, Falcon-Perez, Juan M., Katariina Maaninka, Pia R.‐M. Siljander, Kamali-Moghaddam, Masood, Aransay, Ana M., Eble, Johannes A.,, Halse Østergaard, Rikke,, Falcon-Perez, Juan M.,, Eble, Johannes, Butt, Umar, Butt, Umar,, Østergaard, Rikke Halse, Greco, Dario, Umar Butt, Oxvig, Claus, Ndika, Joseph,, Kjaer-Sorensen, Kasper,, Johannes A. Eble, Dario Greco, Ndika, Joseph, Johanna Puutio, Puutio, Johanna, Puutio, Johanna,, Ostergaard, Rikke, Yuya Hayashi, Kari, Otto K.,, Otto K. Kari, Antonio Federico, Siljander, Pia, Aransay, Ana, Hayashi, Yuya,, Maaninka, Katariina,, Halse Østergaard, Rikke, Siljander, Pia R. -M., Siljander, Pia R. -M.,   +60 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Extracellular Matrix and the Extracellular Environment [PDF]

PROTEOMICS, 2017
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source