Results 61 to 70 of about 1,944,890 (372)
Generalized cable theory for neurons in complex and heterogeneous media [PDF]
Physical Review E 88: 022709, 2013, 2013 Cable theory has been developed over the last decades, usually assuming that the extracellular space around membranes is a perfect resistor. However, extracellular media may display more complex electrical properties due to various phenomena, such as polarization, ionic diffusion or capacitive effects, but their impact on cable properties is not known.
arxiv +1 more source
Modeling extracellular potentials [PDF]
Journal of Computational Neuroscience, 2010 Recordings of extracellular potentials have been, and still are, a main workhorse in the quest for understanding how the brain works. The high-frequency part of the signal, the multi-unit activity (MUA), mainly reflects firing of action potentials in the vicinity of the electrode. The low-frequency part, the local-field potential (LFP), appears largely
Gaute T. Einevoll +2 more
openaire +3 more sources
Electrodiffusion Models of Axon and Extracellular Space Using the Poisson-Nernst-Planck Equations [PDF]
, 2019 In studies of the brain and the nervous system, extracellular signals - as measured by local field potentials (LFPs) or electroencephalography (EEG) - are of capital importance, as they allow to simultaneously obtain data from multiple neurons. The exact biophysical basis of these signals is, however, still not fully understood.
arxiv +1 more source
The extracellular matrix at a glance
Journal of Cell Science, 2010 ![Figure][1] The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical
C. Frantz, K. Stewart, V. Weaver
semanticscholar +1 more source
Neutrophil extracellular traps [PDF]
Current Biology, 2011 What are neutrophil extracellular traps, or NETs? Neutrophils, the most abundant immune cells in humans, are the first line of defense against invading pathogens. They employ a wide array of anti-microbial strategies, most notably phagocytosis, to attack and eliminate pathogens.
Amulic, Borko, Hayes, Garret
openaire +4 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Toxins, 2017 The cyanobacterium Aphanizomenon gracile is the most widely distributed producer of the potent neurotoxin saxitoxin in freshwaters. In this work, total and extracellular saxitoxin and the transcriptional response of three genes linked to saxitoxin ...
Samuel Cirés +3 more
doaj +1 more source
A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles
Journal of Extracellular Vesicles, 2021 Extracellular vesicles (EVs) are small cargo‐bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal
Y. Couch +11 more
semanticscholar +1 more source
Extracellular ATP and Neurodegeneration
Current Drug Target -CNS & Neurological Disorders, 2003 ATP is a potent signaling molecule abundantly present in the CNS. It elicits a wide array of physiological effects and is regarded as the phylogenetically most ancient epigenetic factor playing crucial biological roles in several different tissues. These can range from neurotransmission, smooth muscle contraction, chemosensory signaling, secretion and ...
Volonté, Cinzia +5 more
openaire +3 more sources
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source