Results 261 to 270 of about 2,813,323 (292)

Extracellular DNA: The tip of root defenses?

Plant Science, 2011
This review discusses how extracellular DNA (exDNA) might function in plant defense, and at what level(s) of innate immunity this process might operate. A new role for extracellular factors in mammalian defense has been described in a series of studies.
Martha C, Hawes, Gilberto, Curlango-Rivera, Fushi, Wen, Gerard J, White, Hans D, Vanetten, Zhongguo, Xiong   +5 more
openaire   +2 more sources

Extracellular DNA in oral microbial biofilms

Microbes and Infection, 2015
The extracellular matrix of microbial biofilms is critical for surface adhesion and nutrient homeostasis. Evidence is accumulating that extracellular DNA plays a number of important roles in biofilm integrity and formation on hard and soft tissues in the oral cavity.
Nicholas Jakubovics, James Burgess
openaire   +3 more sources

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma [PDF]

American Journal of Respiratory and Critical Care Medicine, 2019
Abstract Rationale Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL-1β secretion from monocytes and cause airway epithelial cell injury, but the role of eDNA, NETs, and IL-1β in ...
John V Fahy, Mats W. Johansson, Mario Castro   +2 more
exaly   +6 more sources

Characteristics and Changes of DNA in Extracellular Vesicles

DNA and Cell Biology, 2020
Extracellular vesicles (EVs) have been known to carry multiple bioactive molecules, including lipids, mRNA/miRNA, and proteins. However, recent studies show that specific DNAs are also packed into EVs secreted by various cells, which are considered as powerful markers for diagnosis and prognosis of disease.
Xiulin, Chang, Liaoqiong, Fang, Jin, Bai, Zhibiao, Wang   +3 more
openaire   +2 more sources

Extracellular DNA Required for Bacterial Biofilm Formation

Science, 2002
Bacterial biofilms are structured communities of cells enclosed in self-produced hydrated polymeric matrix adherent to an inert or living surface ([1][1]). Formation of these sessile communities and their inherent resistance to antibiotics and host immune attack are at the root of many ...
Whitchurch, C. B., Tolker-Nielsen, T., Ragas, P. C., Mattick, J. S.   +3 more
openaire   +5 more sources

Eosinophil Extracellular DNA Traps In Skin Diseases

Journal of Allergy and Clinical Immunology, 2011
In the skin, eosinophils are found in a broad spectrum of diseases, including infectious diseases.In this study, we investigated whether eosinophil extracellular traps, structures containing DNA in association with eosinophil granule proteins able to bind and kill bacteria, are present in the skin under various pathologic conditions.Immunofluorescence ...
Simon Dagmar, Hoesli Susanne, Roth Nina, Staedler Simon, Yousefi Shida, Simon Hans-Uwe   +5 more
openaire   +4 more sources

Heterochromatic Tandem Repeats in the Extracellular DNA

2016
Only limited sequencing data of the normal extracellular DNA (ecDNA) are currently available. The uptake of the ecDNA by cultured cells and its integration into the host chromatin have been demonstrated. A number of membrane-bearing vesicles in plasma and serum have been shown to carry nucleic acids. The presence of Tandem Repeat (TR) in both apoptotic
Olga I, Podgornaya, Irina N, Vasilyeva, Vladimir G, Bespalov   +2 more
openaire   +2 more sources

Extracellular DNA traps in inflammation, injury and healing

Nature Reviews Nephrology, 2019
Following strong activation signals, several types of immune cells reportedly release chromatin and granular proteins into the extracellular space, forming DNA traps. This process is especially prominent in neutrophils but also occurs in other innate immune cells such as macrophages, eosinophils, basophils and mast cells.
Christoph Daniel, Moritz Leppkes, Luis E. Muñoz, Gunnar Schley, Georg Schett, Martin Herrmann   +5 more
openaire   +2 more sources

Extracellular DNA and histones as thrombus stabiliser

Thrombosis and Haemostasis, 2015
Recent work suggests that extracellular (cell-free) nucleic acids, both DNA and RNA species, as well as extracellular nucleosomes can activate blood coagulation and promote thrombosis in vitro and in vivo (1, 2). Indeed, they substantially contribute to the development of microvascular thrombosis which can act as an intravascular immune response to ...
openaire   +2 more sources

DNA nanotechnology-enabled bioanalysis of extracellular vesicles

Nanoscale Horizons
In this review, we summarize recent breakthroughs in DNA nanotechnology-driven strategies for detecting EV-associated biomarkers (proteins, miRNA, mRNA, glycoRNA), addressing a pressing need for non-invasive diagnostic tools.
Li Pan, Pengfei Wang
openaire   +2 more sources