Results 81 to 90 of about 510,350 (297)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Linking microbial co‐occurrences to soil ecological processes across a woodland‐grassland ecotone

Ecology and Evolution, 2018
Ecotones between distinct ecosystems have been the focus of many studies as they offer valuable insights into key drivers of community structure and ecological processes that underpin function.
Samiran Banerjee, Peter H. Thrall, Andrew Bissett, Marcel G. A. van derHeijden, Alan E. Richardson   +4 more
doaj   +1 more source

The endocytosis gene END3 is essential for the glucose-induced rapid decline of small vesicles in the extracellular fraction in Saccharomyces cerevisiae

Journal of Extracellular Vesicles, 2014
Background: Protein secretion is a fundamental process in all living cells. Gluconeogenic enzymes are secreted when Saccharomyces cerevisiae are grown in media containing low glucose.
Bennett J. Giardina, Kathryn Stein, Hui-Ling Chiang   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Screening for Industrially Important Extracellular Enzymes From Alkalophilic Bacillus Genus [PDF]

, 2003
Alkalophilic Bacillus include industrially important species since they can produce many extracellular enzymes which are active and stable at high pH values.These alkaline enzymes (proteases, amylases, xylanases, cellulases, lipases and pectinases) find ...
Akbalık, Güney
core   +2 more sources

Epigenetic modulation of fungal pathogens: a focus on Magnaporthe oryzae

Frontiers in Microbiology
Epigenetics has emerged as a potent field of study for understanding the factors influencing the effectiveness of human disease treatments and for identifying alternations induced by pathogens in host plants. However, there has been a paucity of research
Hafiz Muhammad Usman Aslam, Hafiz Muhammad Usman Aslam, Mohamad Chikh-Ali, Xin-Gen Zhou, Shouan Zhang, Steven Harris, Ashok K. Chanda, Hasan Riaz, Akhtar Hameed, Saba Aslam, Nabil Killiny   +10 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The effect of fruit on the extracellular enzyme profiles of fungi

Annals of Agricultural and Environmental Medicine, 2020
In recent years, the number of diseases caused by fungal pathogens has increased significantly. Many species of fungi are pathogenic for plants, causing a threat to food production and to humans, and are among the causes of chronic diseases.The aim of the study is to determine the enzyme profiles of fungi, depending on the different types of fruit with
Ewelina Farian, Grażyna Cholewa, Alicja Cholewa, Magdalena Matczuk, Wójcik-Fatla Angelina   +4 more
openaire   +3 more sources

Characterising the Drosophila extracellular superoxide Dismutase gene

, 2010
The indiscriminate action of reactive oxygen species (ROS), if left unregulated, haslong been considered contributory to a range of disease processes within the animalkingdom and is also a factor associated with ageing.
Blackney, Michael James
core