Results 31 to 40 of about 334,235 (263)

Perioperative changes in fluid distribution and haemodynamics in acute high-risk abdominal surgery

Critical Care, 2023
Background Understanding the pathophysiology of fluid distribution in acute high-risk abdominal (AHA) surgery is essential in optimizing fluid management.
Mirjana Cihoric, Henrik Kehlet, Jakob Højlund, Morten Laksáfoss Lauritsen, Katrine Kanstrup, Nicolai Bang Foss   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Phase Angle as a Non-Invasive Biomarker of Fluid Overload in Canine Right Heart Failure: A Bioelectrical Impedance Approach

Animals
Background: Right heart failure (RHF) in dogs is marked by pathological fluid redistribution and extracellular fluid (ECF) accumulation, which intensifies cardiac work-load and disrupts systemic homeostasis.
Zongru Li, Ahmed S. Mandour, Ahmed Farag, Tingfeng Xu, Kazuyuki Terai, Kazumi Shimada, Lina Hamabe, Aimi Yokoi, Ryou Tanaka   +8 more
doaj   +1 more source

Procoagulant extracellular vesicles in amniotic fluid [PDF]

Translational Research, 2017
Embolization of amniotic fluid (AF) into the blood circulation leads to disseminated intravascular coagulation (DIC). Procoagulant phosphatidylserine (PS)- and tissue factor (TF)-exposing extracellular vesicles (EVs) might play an important role in AF embolism-induced DIC.
Lena Hell, Lukas Wisgrill, Cihan Ay, Andreas Spittler, Michael Schwameis, Bernd Jilma, Ingrid Pabinger, Peter Altevogt, Johannes Thaler   +8 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Association between phase angle and ECW/TBW ratio with body composition in individuals with central obesity: a cross-sectional study

Frontiers in Nutrition
BackgroundCentral obesity is closely linked with increased metabolic risk, systemic inflammation, and adverse outcomes. Bioelectrical impedance analysis (BIA) provides phase angle (PhA) and extracellular water to total body water (ECW/TBW) ratio—non ...
Agustinus I. Wayan Harimawan, Anak Agung Sagung Mirah Prabandari, Desak Made Wihandani, I. Made Jawi, I. Wayan Weta, Tjokorda Gde Agung Senapathi, Ni Nyoman Ayu Dewi, Luh Putu Ratna Sundari, Christopher Ryalino, Christopher Ryalino   +9 more
doaj   +1 more source

Towards optimised extracellular vesicle proteomics from cerebrospinal fluid

Scientific Reports, 2023
The proteomic profile of extracellular vesicles (EVs) from cerebrospinal fluid (CSF) can reveal novel biomarkers for diseases of the brain. Here, we validate an ultrafiltration combined with size-exclusion chromatography (UF-SEC) method for isolation of ...
Petra Kangas, Tuula A. Nyman, Liisa Metsähonkala, Cameron Burns, Robert Tempest, Tim Williams, Jenni Karttunen, Tarja S. Jokinen   +7 more
doaj   +1 more source