Results 161 to 170 of about 632,914 (266)

Engineering Highly Cellularized Living Materials via Mechanical Agitation

Advanced Functional Materials, EarlyView.
A mechanical agitation strategy is developed to engineer highly cellularized living materials, achieving cell densities of up to 1 billion cells per milliliter. By precisely tuning properties such as stiffness and toughness in blood clots, the approach is validated in both in vitro and in vivo studies.
Aram Bahmani, Shiyu Liu, Evan Johnston, Weiyi Wan, Xiaoyi Lan, Tianqin Ning, Alexander Nottegar, Ran Huo, Shuaibing Jiang, Jianyu Li   +9 more
wiley   +1 more source

Tethered Exosomes Containing the Matrix Metalloproteinase MT1-MMP Contribute to Extracellular Matrix Degradation. [PDF]

J Extracell Vesicles
Palmulli R, Jackson HK, Edgar JR.
europepmc   +1 more source

Bioinspired Design of a Wet‐Adhesive Cornea Glue Based on Recombinant Human Protein Networks

Advanced Functional Materials, EarlyView.
Natures protein‐based high performance materials e.g. elastin, silk and muscle proteins have been mimicked by a new protein‐hybrid material based on redesigned human partial sequences only, showing high wet‐adhesiveness and elasticity for biomedical applications.
Anna Resch, Matthias C. Huber, Alexander Resch, Andreas Schreiber, Thabo Lapp, Jan Dittrich, Frederic Eisen, Austin Julian Michalec, Viktoria Planz, Adrianna Kolberg, Mathaeus Tschaikowsky, Daniel Böhringer, Maike Windbergs, Thomas Reinhard, Bernd Rolauffs, Bizan N. Balzer, Günther Schlunck, Stefan M. Schiller   +17 more
wiley   +1 more source

Blockade of the Notch Pathway by Inhibition of Fucosylation Ameliorates Chondrocyte Inflammation and Extracellular Matrix Degradation. [PDF]

J Inflamm Res
Zhang Y, Liu M, Wang X, Li N, Chang X, Xu J, Tian F, Wen X, Liu C, Li Y.   +9 more
europepmc   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Substrate stiffness and pressure alter retinal Müller glia response and extracellular matrix production. [PDF]

Biomater Biosyst
Prieto-López L, Pereiro X, Ramírez EJG, Ruzafa N, Alonso A, Franze K, Vecino E.   +6 more
europepmc   +1 more source

Graded Hydroxyapatite Triply Periodic Minimal Surface Structures for Bone Tissue Engineering Applications

Advanced Healthcare Materials, EarlyView.
This study investigates the role of triply periodic minimal structures in load bearing bone tissue engineering applications. Research uses a combination of mechanical testing, material characterization, and in vitro tests to study the impact of TPMS lattice structures (gyroid, lidinoid and split‐P).
Tejas M. Koushik, Catherine M. Miller, Elsa Antunes   +2 more
wiley   +1 more source

Glucocorticoid-Mediated Extracellular Matrix Regulation: Implications for Precision Therapy. [PDF]

Biomedicines
Zhu Y, Zhang Y, Shao J, Jie L.
europepmc   +1 more source

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

Advanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini   +16 more
wiley   +1 more source