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Extracellular matrix structure
Advanced Drug Delivery Reviews, 2016Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell adhesion receptors forming a complex network into which cells reside in all tissues and organs ...
Spyros S. Skandalis +3 more
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2002
Publisher Summary The extracellular matrix comprises a large and varied group of structural macromolecules and their regulatory factors. These extracellular matrix molecules are a part of a finely regulated system of development, maintenance, and repair. The interactions of the extracellular matrix are involved in development and organ formation.
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Publisher Summary The extracellular matrix comprises a large and varied group of structural macromolecules and their regulatory factors. These extracellular matrix molecules are a part of a finely regulated system of development, maintenance, and repair. The interactions of the extracellular matrix are involved in development and organ formation.
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[Phylogenesis of the extracellular matrix].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1993The extracellular matrix constitutes a highly organized intercellular medium. In multicellular animals, it plays important functions for cell cohesion and for the modulation of cell differentiation and behaviour as well. All the investigations conducted in non-vertebrate species have shown that the extracellular matrix is present at the onset of the ...
Garrone, R. +6 more
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Regulation of extracellular matrix degradation by cell—extracellular matrix interactions
Cell Differentiation and Development, 1990An appropriate balance of extracellular matrix synthesis and degradation is required for normal morphogenesis and maintenance of tissue architecture. Extracellular matrix molecules and their receptors, as well as proteinases and their inhibitors, are all involved in matrix remodeling.
Zena Werb +5 more
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Extracellular Matrix and Ageing
2018The extracellular matrix (ECM) provides the environment for many cells types within the body and, in addition to the well recognised role as a structural support, influences many important cell process within the body. As a result, age-related changes to the proteins of the ECM have far reaching consequences with the potential to disrupt many different
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Intrinsic disorder of the extracellular matrix
Molecular BioSystems, 2011The extracellular matrix is very well organized at the supramolecular and tissue levels and little is known on the potential role of intrinsic disorder in promoting its organization. We predicted the amount of disorder and identified disordered regions in the human extracellular proteome with established computational tools.
Vladimir N. Uversky +4 more
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2011
The extracellular matrix is the ordered macromolecular network, on the surface of which and inside the tissue cells are attached to it and to each other, migrate, proliferate or survive. The matrix is composed of protein–carbohydrate complexes, which, in particular, include the glycoproteins carrying out mainly structural or mainly adhesive functions ...
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The extracellular matrix is the ordered macromolecular network, on the surface of which and inside the tissue cells are attached to it and to each other, migrate, proliferate or survive. The matrix is composed of protein–carbohydrate complexes, which, in particular, include the glycoproteins carrying out mainly structural or mainly adhesive functions ...
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The extracellular matrix: Summation
Journal of Cardiac Failure, 2002The development and progression oflef t ventricular (LV) dysfunction and, ultimately, the clinical manifestation ofcongestive heart f (CHF) is due to the summation ofa number ofsystemic, cellular, and molecular abnormalities. The specific constellation ofabnormalities that contribute to the progression ofCHF is disease dependent, but it likely includes
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The extracellular matrix and atherosclerosis
Current Opinion in Lipidology, 1995The vascular extracellular matrix is a collection of vastly different macromolecules organized by entanglement and cross-linking into a biomechanically active polymer that imparts regional tensile strength, viscoelasticity, and compressibility to the atherosclerotic lesion.
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