Results 121 to 130 of about 565,976 (302)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Extracellular matrix proteins are potent agonists of human smooth muscle cell migration

, 1996
Purpose: Extracellular matrix proteins can stimulate smooth muscle cell (SMC) migration by three distinct mechanisms: chemokinesis (nondirected migration in the presence of soluble protein), chemotaxis (directed migration toward soluble protein), and ...
Nelson, Peter R., Yamamura, Shinji, Kent, K.Craig   +2 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

The Neural Cell Adhesion Molecule L1 Potentiates Integrin-Dependent Cell Migration to Extracellular Matrix Proteins

, 2002
The L1 adhesion molecule regulates axon growth and is mutated in the X-linked mental retardation syndrome CRASH (acronym for corpus callosum agenesis, retardation, aphasia, spastic paraplegia, hydrocephalus).
Vishram Kedar, Midkiff, Bentley R., Ralf-Steffen Schmid, Kedar, Vishram, Karsten Thelen, Bentley R. Midkiff, Maness, Patricia F., Panicker, Anitha K., Anitha K. Panicker, Thelen, Karsten, Schmid, Ralf Steffen, Patricia F. Maness   +11 more
core   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Biologic Roles of Gangliosides GM3 and GD3 in the Attachment of Human Melanoma Cells to Extracellular Matrix Proteins

, 1999
The biologic functions of gangliosides GM3 and GD3 in the attachment of human melanoma cells to extracellular matrix proteins (type I and IV collagens, fibronectin, and laminin) were investigated by using the GD3-deficient mutant clone (SK-MEL-28-N1) and
Yasui, Hiroo, Nakano, Junji, Lloyd, Kenneth O., Muto, Masahiko   +3 more
core   +1 more source

Inducible nitric oxide synthase in human lymphomononuclear cells activated by synthetic peptides derived from extracellular matrix proteins

, 1995
Synthetic peptides with sequences present in extracellular matrix proteins are capable of causing the expression of the inducible form of nitric oxide synthase (iNOS), detected by immunocytochemistry, and the release of NO by human lymphomononuclear ...
E. Santiago, Pérez-Mediavilla, L.A., Montuenga, L., M.J. López-Zabalza, Calonge, M., L.A. Pérez-Mediavilla, N. López-Moratalla, López-Zabalza, M.J., López-Moratalla, N., L. Montuenga, M. Calonge, Santiago, E.   +11 more
core   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS AND ENRICHMENT OF POLYUNSATURATED FATTY ACIDS CONTRIBUTE TO BREAST AND LUNG CANCER SENSITIVITY TO SILVER NANOPARTICLES

, 2022
SYNTHESIS OF EXTRACELLULAR MATRIX PROTEINS AND ENRICHMENT OF POLYUNSATURATED FATTY ACIDS CONTRIBUTE TO BREAST AND LUNG CANCER SENSITIVITY TO SILVER NANOPARTICLES Dissertation under the direction of: Ravi N. Singh, Ph.D.
Snyder, Christina Marie
core