Results 101 to 110 of about 565,976 (302)

Complete primary structure of a calcium-dependent serine proteinase capable of degrading extracellular matrix proteins

, 1989
A novel calcium-dependent serine proteinase (CASP) secreted from malignant hamster embryo fibroblast Ni 12C2 degrades extracellular matrix proteins. A complementary DNA encoding CASP has been isolated with the use of oligonucleotide probes synthesized ...
Hirohisa Kinoshita, Isono, Kaichi, Tokunaga, Kastuo, Kastuo Tokunaga, Sakiyama, Hisako, Shinobu Imajoh-Ohmi, Sakiyama, Shigeru, Shigeru Sakiyama, Imajoh-Ohmi, Shinobu, Kaichi Isono, Yoshio Hamada, Kinoshita, Hirohisa, Hamada, Yoshio, Hisako Sakiyama   +13 more
core   +1 more source

Laminin-332 alters connexin profile, dye coupling and intercellular Ca²⁺ waves in ciliated tracheal epithelial cells

Respiratory Research, 2006
Background Tracheal epithelial cells are anchored to a dynamic basement membrane that contains a variety of extracellular matrix proteins including collagens and laminins. During development, wound repair and disease of the airway epithelium, significant
Olsen Colin E, Isakson Brant E, Boitano Scott   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PROTEOMICS OF THE VESSEL WALL

Artery Research, 2013
Proteomics has made tremendous progress over the recent years. Initiatives, such as the Human Protein Atlas project, provide a great resource by capturing the in vivo location of proteins in different tissues and by making these data publically available
Manual Mayr
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Degenerated human intervertebral discs contain autoantibodies against extracellular matrix proteins [PDF]

European Cells & Materials, 2014
Degeneration of intervertebral discs (IVDs) is associated with back pain and elevated levels of inflammatory cells. It has been hypothesised that discogenic pain is a direct result of vascular and neural ingrowth along annulus fissures, which may expose ...
S Capossela, P Schläfli, A Bertolo, T Janner, BM Stadler, T Pötzel, M Baur, JV Stoyanov   +7 more
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effects of early and late antihypertensive treatment on extracellular matrix proteins and mononuclear cells in uninephrectomized SHR

, 1997
Effects of early and late antihypertensive treatment on extracellular matrix proteins and mononuclear cells in uninephrectomized SHR. The efficacy of an early and late treatment with the angiotensin converting enzyme inhibitor lisinopril or the ...
Neumayer, Hans H., Mai, Monika, Dämmrich, Jobst, Geiger, Helmut, Fierlbeck, Wolfgang, Ruchti, Herbert, Schönfeld, Volker, Hugo, Christian   +7 more
core   +1 more source

Leptospira interrogans Secreted Proteases Degrade Extracellular Matrix and Plasma Proteins From the Host

Frontiers in Cellular and Infection Microbiology, 2018
Leptospires are highly motile spirochetes equipped with strategies for efficient invasion and dissemination within the host. Our group previously demonstrated that pathogenic leptospires secrete proteases capable of cleaving and inactivating key ...
Ludmila B. da Silva, Milene C. Menezes, Eduardo S. Kitano, Ana K. Oliveira, Afonso G. Abreu, Afonso G. Abreu, Gisele O. Souza, Marcos B. Heinemann, Lourdes Isaac, Tatiana R. Fraga, Solange M. T. Serrano, Angela S. Barbosa   +11 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source