Results 91 to 100 of about 853,002 (309)

Transcriptome-based systematic identification of extracellular matrix proteins [PDF]

Proceedings of the National Academy of Sciences, 2008
Extracellular matrix (ECM), which provides critical scaffolds for all adhesive cells, regulates proliferation, differentiation, and apoptosis. Different cell types employ customized ECMs, which are thought to play important roles in the generation of so-called niches that contribute to cell-specific functions.
Ri-ichiroh, Manabe, Ko, Tsutsui, Tomiko, Yamada, Mina, Kimura, Itsuko, Nakano, Chisei, Shimono, Noriko, Sanzen, Yutaka, Furutani, Tomohiko, Fukuda, Yasuko, Oguri, Keiko, Shimamoto, Daiji, Kiyozumi, Yuya, Sato, Yoshikazu, Sado, Haruki, Senoo, Shohei, Yamashina, Shiro, Fukuda, Jun, Kawai, Nobuo, Sugiura, Koji, Kimata, Yoshihide, Hayashizaki, Kiyotoshi, Sekiguchi   +21 more
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Inflammation modulates expression of laminin in the central nervous system following ischemic injury

Journal of Neuroinflammation, 2012
Background Ischemic stroke induces neuronal death in the core of the infarct within a few hours and the secondary damage in the surrounding regions over a long period of time.
Ji Kyungmin, Tsirka Stella E
doaj   +1 more source

A simplified aortic ring assay: A useful ex vivo method to assess biochemical and functional parameters of angiogenesis

Matrix Biology Plus, 2020
We present a simplified method for conducting aortic ring assays which yields robust sprouting and high reproducibility targeted towards matrix biologists studying angiogenesis and extracellular matrix signaling.
Aastha Kapoor, Carolyn G. Chen, Renato V. Iozzo   +2 more
doaj   +1 more source

Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN. [PDF]

, 2001
This commentary is a concise discussion of the interactions between bone morphogenetic proteins (BMPs) and their binding proteins in bone and cartilage morphogenesis.
Reddi, AH
core  

Assembly of the Inner Perivitelline Layer, a Homo log of the Mammalian Zona Pellucida: An Immunohistochemical and Ultrastructural Study [PDF]

, 2012
The avian inner perivitelline layer (IPVL), a homologous structure to the mammalian zona pellucida, is deposited between the granulosa cells and the oocyte cell membrane during folliculogenesis. The glycoprotein meshwork of the IPVL forms a 3-dimensional
Bausek N., Bramwell R.K., Callebaut I., Daniela Rodler, Dunbar B.S., Epifano O., Fred Sinowatz, Goudet G., Jovine L., Jovine L., King A.S., Kinoshita M., Lefievre L., Litscher E.S., Menkhorst E., Mori M., Mugnier S., Pan J., Rahman M.A., Rahman M.A., Richardson K.C., Sasanami T., Sasanami T., Sasanami T., Sasanami T., Sato T., Sinowatz F., Smith J., Spargo S.C., Stewart S.G., Takeuchi Y., Tomohiro Sasanami, Waclawek M., Wassarman P.M., Wassarman P.M., Wassarman P.M., Wyburn G.M., Wyburn G.M.   +37 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix

Brazilian Journal of Medical and Biological Research, 2005
The extracellular matrix is a three-dimensional network of proteins, glycosaminoglycans and other macromolecules. It has a structural support function as well as a role in cell adhesion, migration, proliferation, differentiation, and survival.
M. Paez-Pereda, F. Kuchenbauer, E. Arzt, G.K. Stalla   +3 more
doaj   +1 more source

Current approaches for modulation of the nanoscale interface in the regulation of cell behavior [PDF]

, 2018
Regulation of cell behavior in response to nanoscale features has been the focus of much research in recent years and the successful generation of nanoscale features capable of mimicking the natural nanoscale interface has been of great interest in the ...
Dalby, Matthew J., Donnelly, Hannah, Salmeron-Sanchez, Manuel, Sweeten, Paula E.   +3 more
core   +1 more source

The interaction of Thrombospondins with extracellular matrix proteins [PDF]

Journal of Cell Communication and Signaling, 2009
The thrombospondins (TSPs) are a family of five matricellular proteins that appear to function as adapter molecules to guide extracellular matrix synthesis and tissue remodeling in a variety of normal and disease settings. Various TSPs have been shown to bind to fibronectin, laminin, matrilins, collagens and other extracellular matrix (ECM) proteins ...
Tan, Kemin, Lawler, Jack
openaire   +3 more sources